Carbohydrate-Binding Module Family 48

Activities in FamilyModules of approx. 100 residues with glycogen-binding function, appended to GH13 modules. Also found in the beta subunit (glycogen-binding) of AMP-activated protein kinases (AMPK)
Statistics GenBank accession (18965); Uniprot accession (2610); PDB accession (105); 3D entries (29); cryst (1)
All (17945) Archaea (132) Bacteria (16565) Eukaryota (1232) Viruses (2) unclassified (14) Structure (29 - 1 cryst) Characterized (169)
Archaea
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-amylase / cyclomaltodextrinase (PFTA;PF1939) (Amy13) 3.2.1.1
3.2.1.54
Pyrococcus furiosus DSM 3638 AAL82063.1
CAZ78721.1
NP_579668.1
Q8TZP8
4AEF[A,B] 2.34
 α-amylase / maltooligosyltrehalose trehalohydrolase (GTHase) 3.2.1.1
3.2.1.141
Sulfolobus solfataricus KM1 AAR46454.1
BAA11010.1
Q55088
1EH9[A] 3.00
1EHA[A] 3.00
3VGB[A] 2.65
3VGD[A] 2.40
3VGE[A] 2.70
3VGF[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.30
3VGG[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-3)-α-D-Glcp
2.66
3VGH[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-1)-α-D-Glcp
2.60
 isoamylase / 4-α-glucanotransferase (TreX;SSO2094;GlgX;ORF-c06_004;c06021) 2.4.1.25
3.2.1.68
Sulfolobus solfataricus P2 AAK42273.1
CAA69504.1
CAC23738.1
NP_343483.1
P95868
Q7LX99
2VNC[A,B] 3.0
2VR5[A,B] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-β-D-Glcp-(1-4)-ASP
α-D-Glcp
2.8
2VUY[A,B] 3.0
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 type I pullulanase (PulA) 3.2.1.41 Anoxybacillus sp. LM18-11 AEW23439.1  
3WDH[A] 1.75
3WDI[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.20
3WDJ[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.22
 pullulanase (PulA;BaPul13A) (Pul13A) 3.2.1.41 Bacillus acidopullulyticus CAC60156.1
AAX00707.1
ACK18363.1
CAX87014.1
 
2WAN[A] 1.65
 pullulanase type I / glycogen-debranching enzyme (AmyX;BSU29930) 2.4.1.25
3.2.1.33
3.2.1.41
Bacillus subtilis subsp. subtilis str. 168 AAC00283.1
ACH14984.1
AIY94319.1
AQR83021.1
AQR87236.1
CAB14971.1
CAB14971.2
NP_390871.1
C0SPA0
O34587
2E8Y[A,B] 2.11
2E8Z[A,B] 2.20
2E9B[A,B] α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.30
 α-1,4-glucan branching enzyme (GlgB;BE1;cceBE1;cce_2248) 2.4.1.18 Cyanothece sp. ATCC 51142 ACB51598.1 B1WPM8
5GQU[A] 1.85
5GQV[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
3.00
5GQW[A] 1.80
5GQX[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.30
5GQY[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.00
5GQZ[A] 1.85
5GR0[A] 1.95
5GR1[A] α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
2.50
5GR2[A] 1.95
5GR3[A] 2.60
5GR4[A] α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
2.00
5GR5[A] 2.40
5GR6[A] 2.00
 malto-oligosyltrehalose trehalohydrolase (DR0464) 3.2.1.141 Deinococcus radiodurans R1 AAF10042.1
ANC72786.1
NP_294187.1
Q9RX51
2BHU[A] 1.1
2BHY[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
1.5
2BHZ[A] α-D-Glcp-(1-4)-β-D-Glcp
1.2
2BXY[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.75
2BXZ[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.75
2BY0[A] α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.55
2BY1[A] α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.55
2BY2[A] α-D-Glcp
α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.5
2BY3[A] α-D-Glcp-(1-1)-α-D-Glcp
β-D-Glcp
1.5
 branching-enzyme (EcBE;GlgB;EcE24377A_3911) 2.4.1.18 Escherichia coli O139:H28 str. E24377A ABV17243.1 A7ZSW5
5E6Y[A,B,C,D] a-cyclodextrin
2.60
5E6Z[A,B,C,D] b-cyclodextrin
1.88
5E70[A,B,C,D] 2.33
 branching-enzyme (GlgB;EcoBE;b3432) 2.4.1.18 Escherichia coli str. K-12 substr. MG1655 AAA23872.1
AAA58230.1
AAC76457.1
ABX94236.1
AIZ89568.1
ALI38888.1
AMC96315.1
CAP11381.1
NP_417890.1
P07762
1M7X[A] 2.30
3O7Y[A,B,C,D] α-D-Glcp-(1-4)-D-1-deoxy-Glcp
α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp
2.41
3O7Z[A,B,C,D] α-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp
2.55
4LPC[A,B,C,D] α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp
α-D-Glcp-(1-4)-β-D-Glcp
β-D-Glcp
2.39
4LQ1[A,B,C,D] α-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp
2.55
 isoamylase (GlgX;b3431) 3.2.1.68 Escherichia coli str. K-12 substr. MG1655 AAC76456.1
AAA58229.1
AAA98735.1
AIZ89569.1
ALI38889.1
AMC96314.1
CAP11380.1
NP_417889.1
P15067
2WSK[A] 2.25
 pullulanase I (PulA) 3.2.1.41 Fervidobacterium pennivorans Ven5 AAD30387.1 Q9XDB5
cryst    
 pullulanase A (PulA) 3.2.1.41 Klebsiella pneumoniae UNF5023 CAA36431.1
ACH14985.1
P07206
2FGZ[A] 1.75
2FH6[A] α-D-Glcp
1.80
2FH8[A] α-D-Glcp-(1-6)-β-D-Glcp
1.90
2FHB[A] α-D-Glcp-(1-4)-α-D-Glcp
1.80
2FHC[A] α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.85
2FHF[A] α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.65
 branching-enzyme (GlgB;Rv1326c) 2.4.1.18 Mycobacterium tuberculosis H37Rv CAA98090.1
AFN49233.1
CCP44084.1
NP_215842.1
Q10625
3K1D[A] 2.33
 isoamylase (Iam;IsoA) 3.2.1.68 Pseudomonas amyloderamosa SB-15 AAA25854.1 P10342
1BF2[A] 2.00
 pullulanase (PulA;HMPREF9690_00740) 3.2.1.41 Raoultella ornithinolytica 10-5246 EHT13411.1  
2YOC[A,B] 2.88
 STM1560   Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 AAL20478.1
NP_460519.1
Q8ZPF0
3M07[A] 1.40
 pullulanase type I (SAP;GBSCOH1_1122)   Streptococcus agalactiae COH1 CDN66588.1
EAO76676.1
Q3DB05
3FAW[A] 2.10
3FAX[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp
2.40
 glycogen-degrading enzyme (SpuA;PulA;SP0268) 3.2.1.- Streptococcus pneumoniae TIGR4 AAK74446.1
AAT16713.1
ACK14503.1
ACW45222.1
NP_344806.1
Q97SQ7
2YA0[A] 1.85
2YA1[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp
2.25
2YA2[A] α-D-Glcp-(1-1)-<non_carb>
<carb_like_NOJ>
2.37
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 phosphoglucan phosphatase (Sex4;STARCH-EXCESS4;At3g52180;ATPTPKIS1;Dsp4)   Arabidopsis thaliana CAC18328.1
AAL27495.1
AAM61237.1
AAN28817.1
AEE78909.1
AEE78910.1
ANM64923.1
ANM64924.1
CAB41338.1
CAC17593.1
CAC18327.1
NP_566960.1
Q9FEB5
3NME[A,B] 2.40
 isoamylase 1 (Isa1;CrISA1;Sta7) 3.2.1.68 Chlamydomonas reinhardtii CC425 AAP85534.1
AAP88032.1
CAZ78881.1
Q7X8Q2
4J7R[A,B] 2.30
4OKD[A,B] α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-β-D-Glcp-(1-4)-ASP
2.40
 branching-enzyme (Gbe1;HosBE) 2.4.1.18 Homo sapiens AAA58642.1
AAH12098.1
BAD92968.1
BAG54265.1
BAG62313.1
NP_000149.1
Q04446
Q04446
4BZY[A,B,C] 2.75
5CLT[A,B,C] <non_carb>-(1-4)-α-D-6-deoxy-Glcp4N-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.79
5CLW[A,B,C] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
2.80
 AMP-activated protein kinase beta 2 non-catalytic subunit (Prkab2)   Homo sapiens CAH72644.1
AAH53610.1
AAM74153.1
ACM81691.1
AHW56559.1
AHW56664.1
BAF85509.1
BAG57967.1
BAH14376.1
CAA12030.1
NP_005390.1
A8K9V5
O43741
2F15[A] 2.00
4RER[B] L-1,2,6-deoxy-Allp3NMe4Me
b-cyclodextrin
4.05
 AMP-activated protein kinase β-subunit (AMPK;PRKAB1)   Homo sapiens AAD09237.1
AAB71326.1
AAC98897.1
AAD00625.1
AAH01007.1
AAH01056.1
AAH01823.1
AAH17671.1
ACM82906.1
BAG35397.1
BAG62754.1
CAA12024.1
CAA73146.1
NP_006244.2
Q9Y478
4CFE[B,D] L-1,2,6-deoxy-Allp3NMe4Me
3.02
4CFF[B,D] L-1,2,6-deoxy-Allp3NMe4Me
3.92
5ISO[B,D] L-1,2,6-deoxy-Allp3NMe4Me
2.63
5T5T[B] L-1,2,6-deoxy-Allp3NMe4Me
3.46
 limit dextrinase (HvLD99) 3.2.1.41 Hordeum vulgare AAD04189.1
AAD34347.1
AAD34348.1
AAF98802.1
O48541
Q9FYY0
Q9S7S8
2X4B[A] b-cyclodextrin
2.10
2X4C[A] a-cyclodextrin
2.49
2Y4S[A] b-cyclodextrin
2.10
2Y5E[A] a-cyclodextrin
2.49
4AIO[A] 1.90
4CVW[A,B] 2.67
4J3S[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.75
4J3T[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-D-1-deoxy-Glcp
1.60
4J3U[A,B] 1.70
4J3V[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
α-D-Glcp-(1-4)-α-D-Glcp-(1-6)[α-D-Glcp-(1-4)]-α-D-Glcp6SH-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.45
4J3W[A] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-6)[α-D-Glcp-(1-4)]-α-D-Glcp-(1-4)-α-D-Glcp
1.67
4J3X[A] α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.75
 starch-branching enzyme 1 (Sbe1;Rbe1;BEI;OsBEI;Os06g0726400) 2.4.1.18 Oryza sativa Japonica Group BAF20543.1
AAD28284.1
AAP68993.1
AAU99032.1
ABA16988.1
ABL74557.1
ABL74558.1
ACM95329.1
ACY56114.1
AEB33747.1
AEB33748.1
AEB33749.1
AEB33750.1
AEB33751.1
AEB33752.1
AEB33753.1
AEB33754.1
AII21924.1
BAA01584.1
BAA01616.1
BAA01855.1
BAD61712.1
BAD61713.1
BAD61804.1
BAD61805.1
BAG89369.1
BAS99598.1
BAS99599.1
BAS99600.1
Q01401
Q0D9D0
Q7XZP9
3AMK[A] 1.90
3AML[A] 1.70
3VU2[A,B] α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
β-D-Glcp
2.23
 5'-AMP-activated protein kinase, β-subunit (Prkab1)   Rattus norvegicus AAC52579.1
AAH62008.1
CAA64830.1
P80386
1Z0M[A,B,C] b-cyclodextrin
1.91
1Z0N[A,B,C] b-cyclodextrin
1.49
4QFG[B] L-1,2,6-deoxy-Allp3NMe4Me
3.46
4QFR[B] L-1,2,6-deoxy-Allp3NMe4Me
3.34
4QFS[B] L-1,2,6-deoxy-Allp3NMe4Me
3.55
4YEF[A,B,C,D,E,F,G] 1.72
5KQ5[B] L-1,2,6-deoxy-Allp3NMe4Me
3.41
5T5T[B] L-1,2,6-deoxy-Allp3NMe4Me
3.46
5UFU[B] L-1,2,6-deoxy-Allp3NMe4Me
3.45
 5'-AMP-activated protein kinase subunit β-2 (Prkab2)   Rattus norvegicus AAF01293.1
AAH78821.1
NP_072149.1
Q9QZH4
2LU3[A] NMR
2LU4[A] NMR
4Y0G[A,B] 1.60
4YEE[A,B,C,D,E,F,G,H,I,J, 2.00
 YGL208W (Sip2;Spm2)   Saccharomyces cerevisiae S288c AAC37420.1
CAA78503.1
CAA96922.1
NP_011307.1
P34164
2QLV[B] 2.60
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