Carbohydrate-Binding Module Family 40

Known Activities	Modules of approx. 200 residues, found at the N-terminus of GH33 sialidases. Can also be found inserted in the β-propeller of GH33 sialidases. The sialic acid binding function has been demonstrated for the N-terminal CBM40 of Vibrio cholerae sialidase (Moustafa et al. (2004) J Biol Chem 279:40819-26) (PMID: 15226294).
3D Structure Status	lectin-like
External resources	HOMSTRAD; InterPro; PFAM;
Statistics	GenBank accession (110); Uniprot accession (52); PDB accession (14); 3D entries (4); cryst (0)

Summary

All (84) Bacteria (83) Eukaryota (1) Structure (4 ) Characterized (11)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
exo-α-sialidase (NanH)	3.2.1.18	Clostridium perfringens A99	CAA60796.1	Q59310
exo-α-sialidase (NanJ;CPE0553)	3.2.1.18	Clostridium perfringens str. 13	BAB80259.1 NP_561469.1	Q8XMY5	2V73[A,B]
exo-α-sialidase (NanI;CPE0725)	3.2.1.18	Clostridium perfringens str. 13	BAB80431.1 NP_561641.1	Q8XMG4
sialidase (NanH;SiaH)	3.2.1.18	Clostridium tertium	CAA69951.1	P77848
sialidase (NanH)	3.2.1.18	Erysipelothrix rhusiopathiae FUJISAWA	BAB40435.1	Q9AJR8
sialidase A (NanA)	3.2.1.18	Streptococcus pneumoniae 6	ACJ76903.1 CAA51473.1	B8XTT3 P62575 Q59959
sialidase B (NanB)	3.2.1.18	Streptococcus pneumoniae 6	AAC44396.1 AAW08718.1	Q54727
(trans-)sialidase B (NanB;SP1687)	2.4.1.- 3.2.1.18	Streptococcus pneumoniae TIGR4	AAK75766.1 NP_346126.1		2JKB[A] 2VW0[A] 2VW1[A] 2VW2[A]
sialidase (NanH)	3.2.1.18	Vibrio cholerae 569B 395	AAA27546.1 AAA27547.1	P37060.1	1KIT[A] 1W0O[A] 1W0P[A] 2W68[A,B,C]
sialidase (NanH)	3.2.1.18	Vibrio cholerae 569B 395	AAA27546.1	P37060.1	1KIT[A] 1W0O[A] 1W0P[A]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
sialidase L	3.2.1.18	Macrobdella decora	AAC47263.1	Q27701	1SLI[A] 1SLL[A] 2SLI[A] 3SLI[A] 4SLI[A]

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.