Carbohydrate-Binding Module Family 40

Activities in FamilyModules of approx. 200 residues, found at the N-terminus of GH33 sialidases. Can also be found inserted in the β-propeller of GH33 sialidases. The sialic acid binding function has been demonstrated for the N-terminal CBM40 of Vibrio cholerae sialidase (Moustafa et al. (2004) J Biol Chem 279:40819-26) (PMID: 15226294).
3D Structure Statuslectin-like
External resourcesHOMSTRAD;
Statistics GenBank accession (304); Uniprot accession (83); PDB accession (66); 3D entries (7); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 sialidase (NanA) (fragment) 3.2.1.18 Clostridium chauvoei JF4135 CAR82361.1 E1UGY4  
 exo-α-sialidase 'large' (NanH) 3.2.1.18 Clostridium perfringens A99 CAA60796.1 Q59310  
 sialidase (CpNanI;CPF_0721) 3.2.1.18 Clostridium perfringens ATCC 13124 ABG83208.1 Q0TT67 5FRA[A,B,C,D,E,F]
5FRE[A,B,C]
 exo-α-sialidase (NanJ;CPE0553) 3.2.1.18 Clostridium perfringens str. 13 BAB80259.1
NP_561469.1
Q8XMY5 2V73[A,B]
 exo-α-sialidase (NanI;CPSA;CPE0725) 3.2.1.18 Clostridium perfringens str. 13 BAB80431.1
NP_561641.1
Q8XMG4  
 sialidase (NanH;SiaH) 3.2.1.18 Clostridium tertium CAA69951.1 P77848  
 sialidase (NanH) 3.2.1.18 Erysipelothrix rhusiopathiae FUJISAWA BAB40435.1 Q9AJR8  
 anhydrosialidase (RgNanH;HMPREF1201_01421) (intramolecular) 4.2.2.15 Ruminococcus gnavus ETD19277.1    
 sialidase 3.2.1.18 Streptococcus intermedius ATCC 27335 BAJ15290.1 E0CZJ4  
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
4C1W[A]
4C1X[A]
4ZXK[A,B]
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1
Q54727  
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 sialidase (NanA;SPD_1504) 3.2.1.18 Streptococcus pneumoniae D39 ABJ55437.1 Q04J78  
 neuraminidase (NanC) 3.2.1.18 Streptococcus pneumoniae G54 ACF56230.1 B5E561 4YW0[A,B]
4YW1[A,B]
4YW2[A,B]
4YW3[A,B]
4YW4[A,B]
4YW5[A,B]
4YZ1[A,B]
4YZ2[A,B]
4YZ3[A,B]
4YZ4[A,B]
4YZ5[A,B]
5F9T[A,B]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1
AAA27547.1
P37060 1KIT[A]
1W0O[A]
1W0P[A]
2W68[A,B,C]
6EKS[A]
6EKU[A]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
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