Carbohydrate-Binding Module Family 40

Activities in FamilyModules of approx. 200 residues, found at the N-terminus of GH33 sialidases. Can also be found inserted in the β-propeller of GH33 sialidases. The sialic acid binding function has been demonstrated for the N-terminal CBM40 of Vibrio cholerae sialidase (Moustafa et al. (2004) J Biol Chem 279:40819-26) (PMID: 15226294).
3D Structure Statuslectin-like
External resourcesHOMSTRAD;
Statistics GenBank accession (299); Uniprot accession (83); PDB accession (64); 3D entries (7); cryst (0)
| 1 | 2 | 3 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35169.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07843.1
CCM07838.1
   
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 neuraminidase   Streptococcus pneumoniae ST556 AFC95272.1    
 neuraminidase   Streptococcus pneumoniae Taiwan19F-14 ACO23538.1    
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11935   Streptococcus pneumoniae TCH8431/19A ADI70163.1 D6ZMP9  
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 neuraminidase (NanA;SpneT_02001817)   Streptococcus pneumoniae TIGR4 ZP_01407762.1    
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
ABA35893.1
NP_345784.1
Q97Q99  
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R82E6 ACJ76895.1 B8XTS5  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R89G3 ACJ76897.1
ACJ76898.1
B8XTS7  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R98A5 ACJ76899.1 B8XTS9  
 SNAG_0542 (Nana_2)   Streptococcus sp. NPS 308 BAV79420.1    
 AXF18_00720   Streptococcus sp. oral taxon 064 W10853 ANR74557.1    
 AXE83_09040   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97713.1    
 AXE83_09045   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97714.1    
 V470_02445   Streptococcus sp. VT 162 AHZ47303.1    
 SSUA7_0867   Streptococcus suis A7 AER44191.1    
 ORF (fragment)   uncultured bacterium APO30899.1    
 PL85_10365   Vibrio anguillarum DSM 21597 AQM03037.1    
 PO29_12530   Vibrio anguillarum HI610 AQM17087.1    
 CMV05_04215   Vibrio anguillarum VIB12 ATC56928.1    
 CK207_04320   Vibrio anguillarum VIB43 ASW80374.1    
 VAB027_2456 (NanH)   Vibrio cholerae 10432-62 AKB08334.1    
 neuraminidase (NanH)   Vibrio cholerae 13 AIL52586.1    
 EN18_12065   Vibrio cholerae 2012EL-2176 AIT29775.1    
 BBB50_05755   Vibrio cholerae 2740-80 ANR87208.1    
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1
AAA27547.1
P37060 1KIT[A]
1W0O[A]
1W0P[A]
2W68[A,B,C]
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2 Q5IB64
Q5IB64
 
 neuraminidase   Vibrio cholerae C5 APF49319.1    
 ASZ81_01775   Vibrio cholerae CRC1106 APF56916.1    
 neuraminidase   Vibrio cholerae CRC711 APF53177.1    
 ASZ88_01723 (NanH)   Vibrio cholerae E1320 APF68105.1    
 neuraminidase   Vibrio cholerae E506 APF60361.1    
 neuraminidase   Vibrio cholerae E9120 APF71815.1    
 A6J62_08325   Vibrio cholerae FDAARGOS_223 ARB80595.1    
 neuraminidase   Vibrio cholerae IEC224 AFC58601.1    
 VCLMA_A1545   Vibrio cholerae LMA3984-4 AEA78761.1    
 neuraminidase   Vibrio cholerae M2140 APF75003.1    
 neuraminidase (NanH)   Vibrio cholerae M66-2 ACP06029.1 C3LNA3  
 VCD_002587   Vibrio cholerae MJ-1236 ACQ60753.1 C3NPP4  
 MS6_1556   Vibrio cholerae MS6 BAP03211.1    
 neuraminidase   Vibrio cholerae NCTC5395 APF79274.1    
 neuraminidase (fragment)   Vibrio cholerae NCTC9420 APF83226.1    
 neuraminidase (NanH)   Vibrio cholerae O1 biovar El Tor R-5879 AND74814.1    
 VC1784   Vibrio cholerae O1 biovar El Tor str. N16961 AAF94933.1
NP_231419.1
P0C6E9  
 neuraminidase (NanH)   Vibrio cholerae O1 str. 2010EL-1786 AET26878.1    
 N900_05420   Vibrio cholerae O1 str. KW3 ALJ63797.1    
 VC0395_A1381   Vibrio cholerae O395 ABQ19703.1
ACP09894.1
A5F7A4  
 EN12_08655   Vibrio cholerae TSY216 AKO75305.1    
 AL543_04635   Vibrio mimicus ATCC 33654 AMG02310.1    
 VM_15685   Vibrio mimicus SCCF01 AOW84156.1    
 BSZ05_24155   Vibrio shilonii QT6D1 ASI92859.1    
 BME96_15045   Virgibacillus halodenitrificans PDB-F2 APC49429.1    
 CFK37_08545   Virgibacillus sp. LM2416 ASK62205.1    
 X953_15560   Virgibacillus sp. SK37 AIF44402.1    
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