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Carbohydrate-Binding Module Family 40

Known ActivitiesModules of approx. 200 residues, found at the N-terminus of GH33 sialidases. Can also be found inserted in the b-propeller of GH33 sialidases. The sialic acid binding function has been demonstrated for the N-terminal CBM40 of Vibrio cholerae sialidase (Moustafa et al. (2004) J Biol Chem 279:40819-26) (PMID: 15226294).
3D Structure Statuslectin-like
External resourcesHOMSTRAD;
Statistics GenBank accession (145); Uniprot accession (84); PDB accession (31); 3D entries (5); cryst (0)
Summary
All (123) Bacteria (122) Eukaryota (1) Structure (5 ) Characterized (15)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 NanA (fragment)   Clostridium chauvoei JF3703 CAR82360.1 E1UGY3  
 sialidase (NanA) (fragment) 3.2.1.18 Clostridium chauvoei JF4135 CAR82361.1 E1UGY4  
 exo-α-sialidase 'large' (NanH) 3.2.1.18 Clostridium perfringens A99 CAA60796.1 Q59310  
 CPF_0721   Clostridium perfringens ATCC 13124 ABG83208.1 Q0TT67  
 CPF_0532   Clostridium perfringens ATCC 13124 ABG84247.1 Q0TTQ4  
 exo-α-sialidase (NanJ;CPE0553) 3.2.1.18 Clostridium perfringens str. 13 BAB80259.1
NP_561469.1		 Q8XMY5 2V73[A,B]
 exo-α-sialidase (NanI;CPE0725) 3.2.1.18 Clostridium perfringens str. 13 BAB80431.1
NP_561641.1		 Q8XMG4  
 ZP_02867864.1   ZP_02867864.1 B1C387  
 ZP_02867864.1   ZP_02867864.1 B1C387  
 sialidase (NanH;SiaH) 3.2.1.18 Clostridium tertium CAA69951.1 P77848  
 sialidase (NanH) 3.2.1.18 Erysipelothrix rhusiopathiae FUJISAWA BAB40435.1 Q9AJR8  
 neuraminidase (Nanh.1)   Erysipelothrix rhusiopathiae str. Fujisawa BAK31357.1    
 PRU_2749 (probable fragment)   Prevotella ruminicola 23 ADE82909.1 D5EY33  
 Spea_1515   Shewanella pealeana ATCC 700345 ABV86840.1 A8H2Q3  
 Spea_1515   Shewanella pealeana ATCC 700345 ABV86840.1 A8H2Q3  
 Spea_1515   Shewanella pealeana ATCC 700345 ABV86840.1 A8H2Q3  
 SPSE_1611 (NanB)   Staphylococcus pseudintermedius ED99 ADX76869.1    
 SEQ_1612   Streptococcus equi subsp. equi 4047 CAW94606.1 C0MAP0  
 SeseC_01852   Streptococcus equi subsp. zooepidemicus ATCC 35246 AEJ25722.1    
 SZO_05310   Streptococcus equi subsp. zooepidemicus H70 CAW98510.1    
 Sez_1425 (NanA)   Streptococcus equi subsp. zooepidemicus MGCS10565 ATCC BAA1716 ACG62759.1 B4U442  
 sialidase 3.2.1.18 Streptococcus intermedius ATCC 27335 BAJ15290.1 E0CZJ4  
 SCIM_0012 (NanA)   Streptococcus intermedius JTH08 BAM22666.1    
 smi_0601 (NanA)   Streptococcus mitis B6 CBJ21850.1 D3H7K8  
 neuraminidase (NanA)   Streptococcus mitis R83E2 ACJ76896.1 B8XTS6  
 SOR_0548 (NanA)   Streptococcus oralis Uo5 CBZ00210.1    
 Sequence 3172 from patent US 7074914   Streptococcus pneumoniae ABI03133.1
ABI08174.1
ABJ31690.1
ABJ49303.1
ABL17046.1
ACK13592.1
ACW44311.1		    
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 ACJ76903.1
CAA51473.1		 B8XTT3
P62575
Q59959		  
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1		 Q54727  
 SP670_0950   Streptococcus pneumoniae 670-6B ADM91015.1 E0TMG6  
 SP670_1783   Streptococcus pneumoniae 670-6B ADM91835.1 E0TSF6  
 SP670_1776   Streptococcus pneumoniae 670-6B ADM91828.1 E0TSE9  
 SP70585_1726   Streptococcus pneumoniae 70585 ACO17953.1 C1C8S5  
 neuraminidase (NanA)   Streptococcus pneumoniae A66.1 ACJ76912.1 B8XTU2  
 SPAP_1700   Streptococcus pneumoniae AP200 ADM85284.1 E0SWG1  
 SPAP_1354   Streptococcus pneumoniae AP200 ADM84940.1 E0SUC9  
 SPAP_1692 (fragment)   Streptococcus pneumoniae AP200 ADM85276.1 E0SWF3  
 SPAP_1695 (fragment)   Streptococcus pneumoniae AP200 ADM85279.1 E0SWF6  
 neuraminidase   Streptococcus pneumoniae ATCC 700669 CAR69021.1 B8ZK40  
 neuraminidase (NanB)   Streptococcus pneumoniae ATCC 700669 CAR69459.1 B8ZMF2  
 neuraminidase (NanA)   Streptococcus pneumoniae ATCC 700669 CAR69464.1 B8ZMF7  
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 SPCG_1660 (NanB)   Streptococcus pneumoniae CGSP14 ACB90912.1 B2IRU3  
 SPCG_1665   Streptococcus pneumoniae CGSP14 ACB90917.1
ACJ76905.1
ACJ76908.1
ACJ76909.1
ACJ76932.1		 B2IRU8  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL25 = 340 132217 CAI94554.1 Q4LB84  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL37 = 162 GM123 CAI94567.1 Q4LB80  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL50 = 352- E/208 CAI94551.1 Q4LB89  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL54 = 145 GM92 CAI94566.1 Q4LB86  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL56 = 381 110K/70 CAI94568.1 Q4LB79  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CL57 = 398 CAI94571.1 Q4LB81  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR13 = 884 141926 CAI94555.1 Q4LB83  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR33 = 910 13B-15F CAI94565.1 Q4LB88  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR50 = 967 12B-5L CAI94552.1 Q4LB87  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR51 = 946 12B-21H CAI94556.1 Q4LB82  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae CR8 = 956 12B-11F CAI94553.1 Q4LB85  
 SPD_1499   Streptococcus pneumoniae D39 ABJ55283.1 Q04J83  
 sialidase (NanA;SPD_1504) 3.2.1.18 Streptococcus pneumoniae D39 ABJ55437.1 Q04J78  
 neuraminidase (NanA)   Streptococcus pneumoniae G54 ACF55470.1
ACJ76910.1
ACJ76928.1		 B5E741  
 neuraminidase (NanB)   Streptococcus pneumoniae G54 ACF54964.1 B5E736  
 neuraminidase (NanC)   Streptococcus pneumoniae G54 ACF56230.1 B5E561  
 HMPREF1038_01669 (NanB)   Streptococcus pneumoniae gamPNI0373 AFS43693.1    
 HMPREF1038_01674   Streptococcus pneumoniae gamPNI0373 AFS43698.1    
 SPH_1797 (NanA)   Streptococcus pneumoniae Hungary19A-6 ACA36706.1
ACJ76911.1
ACJ76914.1
ACJ76922.1
ACJ76926.1
ACO19629.1		 B1I751  
 SPH_1468   Streptococcus pneumoniae Hungary19A-6 ACA36743.1 B1ICD8  
 INV104_14370 (NanB)   Streptococcus pneumoniae INV104 CBW37118.1 E1XSK8  
 INV104_07470   Streptococcus pneumoniae INV104 CBW36430.1 E1XQR4  
 INV104_14420 (NanA)   Streptococcus pneumoniae INV104 CBW37123.1 E1XSL3  
 neuraminidase   Streptococcus pneumoniae INV200 CBW34434.1 E1XJC0  
 neuraminidase (NanB)   Streptococcus pneumoniae INV200 CBW35142.1 E1XL92  
 SPNINV200_15140 (NanA)   Streptococcus pneumoniae INV200 CBW35147.1 E1XL97  
 SPJ_1581   Streptococcus pneumoniae JJA ACO19530.1 C1CFQ7  
 SPJ_1242 (NanC)   Streptococcus pneumoniae JJA ACO20071.1 C1CET1  
 SPNOXC_14830   Streptococcus pneumoniae OXC141 CBW33136.1 E1XCC8  
 SPNOXC_14880   Streptococcus pneumoniae OXC141 CBW33141.1 E1XCD3  
 SPP_1704   Streptococcus pneumoniae P1031 ACO21913.1 C1CM25  
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae PN13 CAI94569.1 Q4LB78  
 sialidase A (NanA)   Streptococcus pneumoniae R6 AAL00340.1
ACJ76904.1
ACO21301.1
NP_359129.1		 P62576  
 NanB   Streptococcus pneumoniae R6 AAL00335.1
NP_359124.1		 Q8CWP8  
 neuraminidase (NanA)   Streptococcus pneumoniae SP14-BS69 ACJ76929.1
ACO23538.1		 B8XTV9  
 neuraminidase (NanA)   Streptococcus pneumoniae SP9-BS68 ACJ76927.1
ACO17645.1		 B8XTV7  
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36239.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36244.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33190.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33195.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31205.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31210.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35164.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35169.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07838.1
CCM07843.1		    
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 neuraminidase   Streptococcus pneumoniae ST556 AFC95272.1    
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11935   Streptococcus pneumoniae TCH8431/19A ADI70163.1 D6ZMP9  
 (trans-)sialidase B (NanB;SP1687) 2.4.1.-
3.2.1.18		 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1		   2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
 neuraminidase (NanA;SpneT_02001817)   Streptococcus pneumoniae TIGR4 ZP_01407762.1    
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
ABA35893.1
NP_345784.1		 Q97Q99  
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R82E6 ACJ76895.1 B8XTS5  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R89G3 ACJ76897.1
ACJ76898.1		 B8XTS7  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R98A5 ACJ76899.1 B8XTS9  
 SSUA7_0867   Streptococcus suis A7 AER44191.1    
 sialidase / neuraminidase (NanH;VcNA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 P37060 1KIT[A]
1W0O[A]
1W0P[A]
 sialidase / neuraminidase (NanH;VcNA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1
AAA27547.1		 P37060 1KIT[A]
1W0O[A]
1W0P[A]
2W68[A,B,C]
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.2 Q5IB64
Q5IB64		  
 NanH   Vibrio cholerae AMAZONIA 3509 AAW31751.1
AAW31751.2		 Q5IB64
Q5IB64		  
 neuraminidase   Vibrio cholerae IEC224 AFC58601.1    
 neuraminidase   Vibrio cholerae IEC224 AFC58601.1    
 VCLMA_A1545   Vibrio cholerae LMA3894-4 AEA78761.1    
 VCLMA_A1545   Vibrio cholerae LMA3894-4 AEA78761.1    
 neuraminidase (NanH)   Vibrio cholerae M66-2 ACP06029.1 C3LNA3  
 neuraminidase (NanH)   Vibrio cholerae M66-2 ACP06029.1 C3LNA3  
 VCD_002587   Vibrio cholerae MJ-1236 ACQ60753.1 C3NPP4  
 VCD_002587   Vibrio cholerae MJ-1236 ACQ60753.1 C3NPP4  
 VC1784   Vibrio cholerae O1 biovar El Tor str. N16961 AAF94933.1
NP_231419.1		 P0C6E9  
 VC1784   Vibrio cholerae O1 biovar El Tor str. N16961 AAF94933.1
NP_231419.1		 P0C6E9  
 neuraminidase (NanH)   Vibrio cholerae O1 str. 2010EL-1786 AET26878.1    
 neuraminidase (NanH)   Vibrio cholerae O1 str. 2010EL-1786 AET26878.1    
 neuraminidase (NanH)   Vibrio cholerae O1 str. 2010EL-1786 AET26878.1    
 neuraminidase (NanH)   Vibrio cholerae O1 str. 2010EL-1786 AET26878.1    
 VC0395_A1381   Vibrio cholerae O395 ABQ19703.1
ACP09894.1		 A5F7A4  
 VC0395_A1381   Vibrio cholerae O395 ABQ19703.1
ACP09894.1		 A5F7A4  
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 sialidase L 3.2.1.18
3.2.1.18		 Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
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