Carbohydrate-Binding Module Family 18

Activities in FamilyModules of approx. 40 residues. The chitin-binding function has been demonstrated in many cases. These modules are found attached to a number of chitinase catalytic domains, but also in non-catalytic proteins either in isolation or as multiple repeats.
External resourcesHOMSTRAD; SMART;
Statistics GenBank accession (2487); Uniprot accession (100); PDB accession (46); 3D entries (31); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 antimicrobial peptide (Ac-AMP2;Acamp2)   Amaranthus caudatus CAA51210.1
ABK58702.1
 
1MMC[A] NMR
1ZNT[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
NMR
1ZUV[A] NMR
1ZWU[A] NMR
 lectin   Arundo donax    
6STM[A] 1.70
6STO[A] α-D-GlcpNAc
β-D-Galp-(1-4)-β-D-GlcpNAc
1.50
6STP[A] α-D-Neup5Ac
1.60
6STQ[A] α-D-GlcpNAc
1.50
6STR[A] β-D-GlcpNAc
1.80
6STN[A] α-D-GlcpNAc
1.75
 lectin   Arundo donax    
6STM[A] 1.70
6STO[A] α-D-GlcpNAc
β-D-Galp-(1-4)-β-D-GlcpNAc
1.50
6STP[A] α-D-Neup5Ac
1.60
6STQ[A] α-D-GlcpNAc
1.50
6STR[A] β-D-GlcpNAc
1.80
6STN[A] α-D-GlcpNAc
1.75
 lectin   Arundo donax    
6STM[A] 1.70
6STO[A] α-D-GlcpNAc
β-D-Galp-(1-4)-β-D-GlcpNAc
1.50
6STP[A] α-D-Neup5Ac
1.60
6STQ[A] α-D-GlcpNAc
1.50
6STR[A] β-D-GlcpNAc
1.80
6STN[A] α-D-GlcpNAc
1.75
 lectin   Arundo donax    
6STM[A] 1.70
6STO[A] α-D-GlcpNAc
β-D-Galp-(1-4)-β-D-GlcpNAc
1.50
6STP[A] α-D-Neup5Ac
1.60
6STQ[A] α-D-GlcpNAc
1.50
6STR[A] β-D-GlcpNAc
1.80
6STN[A] α-D-GlcpNAc
1.75
 peptidoglycan recognition protein (Pgrp3)   Branchiostoma belcheri tsingtauense ALI16132.1  
4Z8I[A] 2.70
 anti-microbial peptide   Chenopodium quinoa    
5ZV6[A] NMR
 chitinase B (ChiB)   Ficus microcarpa BCS90539.1  
7V91[A] 1.60
7V92[A] 1.61
 hevein (major) (Hev1)   Hevea brasiliensis AAA33357.1
AAG16225.2
AAO63574.1
AAP01387.1
AAQ68982.1
ACP58748.1
 
1HEV[A] NMR
1Q9B[A] 1.50
1T0W[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
NMR
4WP4[A] 1.43
 chitinase-like protein 1 / allergen (Rq30;Clp1;Chi-L1;HbCLP1;Hev b 11.0101)   Hevea brasiliensis AHF88836.1
CAC42881.1
 
4MPI[A,B] 1.60
 morintide (Mo1) (partial)   Moringa oleifera AQR58371.1
AQR58372.1
 
5WUZ[A] NMR
 chitinase (Cht2;OsChia1b;Cht-2;Os05g0399300;RCC2)   Oryza sativa Japonica Group BAA03750.1
BAF17390.1
BAS93903.1
CAA40107.1
A0A0P0WM49
Q43294
Q7DNA1
2DKV[A] 2.00
 lectin-D1/D2 (PL-D2) (partial)   Phytolacca americana    
1UHA[A] 1.50
1ULM[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
1.80
1ULN[A] 1.65
 lectin-D1/D2 (PL-D2) (partial)   Phytolacca americana    
1UHA[A] 1.50
1ULM[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
1.80
1ULN[A] 1.65
 antimicrobial peptide (AMP-2;SmAMP2.2a;SmAMP2-2c)   Stellaria media CBJ21249.1  
2N1S[A] NMR
 agglutinin 1 (WGA1)   Triticum aestivum AAA34256.1  
1WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
2CWG[A,B] 2.00
2UVO[A,B,E,F] α-D-GlcpNAc
β-D-GlcpNAc
1.40
2UWG[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
2X3T[A,B,C,D] α-D-GlcpNAc-(1-1)-<non_carb>
2.749
4AML[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
7WGA[A,B] 2.00
 agglutinin 1 (WGA1)   Triticum aestivum AAA34256.1  
1WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
2CWG[A,B] 2.00
2UVO[A,B,E,F] α-D-GlcpNAc
β-D-GlcpNAc
1.40
2UWG[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
2X3T[A,B,C,D] α-D-GlcpNAc-(1-1)-<non_carb>
2.749
4AML[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
7WGA[A,B] 2.00
 agglutinin 1 (WGA1)   Triticum aestivum AAA34256.1  
1WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
2CWG[A,B] 2.00
2UVO[A,B,E,F] α-D-GlcpNAc
β-D-GlcpNAc
1.40
2UWG[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
2X3T[A,B,C,D] α-D-GlcpNAc-(1-1)-<non_carb>
2.749
4AML[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
7WGA[A,B] 2.00
 agglutinin 1 (WGA1)   Triticum aestivum AAA34256.1  
1WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
2CWG[A,B] 2.00
2UVO[A,B,E,F] α-D-GlcpNAc
β-D-GlcpNAc
1.40
2UWG[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
2X3T[A,B,C,D] α-D-GlcpNAc-(1-1)-<non_carb>
2.749
4AML[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.60
7WGA[A,B] 2.00
 agglutinin 2 (WGA2)   Triticum aestivum AAA34258.1  
2WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
9WGA[A,B] 1.80
 agglutinin 2 (WGA2)   Triticum aestivum AAA34258.1  
2WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
9WGA[A,B] 1.80
 agglutinin 2 (WGA2)   Triticum aestivum AAA34258.1  
2WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
9WGA[A,B] 1.80
 agglutinin 2 (WGA2)   Triticum aestivum AAA34258.1  
2WGC[A,B] α-D-Neup5Ac-(2-3)-β-D-Galp-(1-4)-β-D-Glcp
2.20
9WGA[A,B] 1.80
 agglutinin 3 (WGA3)   Triticum aestivum AAA34257.1  
1K7T[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp
2.40
1K7U[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
2.20
1K7V[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp-(1-4)-β-D-Glcp
2.20
1WGT[A,B] 1.90
2UWZ[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.7
2X52[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.70
 agglutinin 3 (WGA3)   Triticum aestivum AAA34257.1  
1K7T[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp
2.40
1K7U[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
2.20
1K7V[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp-(1-4)-β-D-Glcp
2.20
1WGT[A,B] 1.90
2UWZ[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.7
2X52[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.70
 agglutinin 3 (WGA3)   Triticum aestivum AAA34257.1  
1K7T[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp
2.40
1K7U[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
2.20
1K7V[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp-(1-4)-β-D-Glcp
2.20
1WGT[A,B] 1.90
2UWZ[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.7
2X52[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.70
 agglutinin 3 (WGA3)   Triticum aestivum AAA34257.1  
1K7T[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp
2.40
1K7U[A,B] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc
2.20
1K7V[A,B] β-D-GlcpNAc-(1-6)-β-D-Galp-(1-4)-β-D-Glcp
2.20
1WGT[A,B] 1.90
2UWZ[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.7
2X52[A,B] α-D-GlcpNAc-(1-1)-<non_carb>
1.70
 antimicrobial peptide 1b / H1 (Wamp-1;WAMP-1b;Tk-AMP-H1)   Triticum kiharae CCD30733.1
CCD30735.1
 
2LB7[A] NMR
 chitinase / agglutinin isolectin I (Uda1;UDA)   Urtica dioica AAA34219.1
AAB23919.1
AAD03577.1
AAD03579.1
AAD03581.1
AAD03583.1
AAD03585.1
AAD03614.1
AAD03819.1
AAD03821.1
AAE52532.1
ABC04850.1
P11218
Q9S7C2
Q9S7K1
Q9S7W3
Q9SYR1
1EIS[A] 1.66
1EN2[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
1.40
1ENM[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
1.90
1IQB[A,B] 1.90
 chitinase / agglutinin isolectin I (Uda1;UDA)   Urtica dioica AAA34219.1
AAB23919.1
AAD03577.1
AAD03579.1
AAD03581.1
AAD03583.1
AAD03585.1
AAD03614.1
AAD03819.1
AAD03821.1
AAE52532.1
ABC04850.1
P11218
Q9S7C2
Q9S7K1
Q9S7W3
Q9SYR1
1EIS[A] 1.66
1EN2[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
1.40
1ENM[A] β-D-GlcpNAc-(1-4)-β-D-GlcpNAc-(1-4)-D-1-deoxy-GlcpNAc
1.90
1IQB[A,B] 1.90
unclassified
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 avenatide aV1   unidentified    
6M5C[A] NMR
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