Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (6439); Uniprot accession (901); PDB accession (150); 3D entries (58); cryst (1)
All (6278) Archaea (23) Bacteria (5611) Eukaryota (599) Viruses (32) unclassified (13) Structure (58 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 pierisin-1b   Pieris rapae ADU33873.1    
 pierisin-1b   Pieris rapae ADU33873.1    
 pierisin-1   Pieris rapae BAL61208.1
BAA84491.1
   
 pierisin-1   Pieris rapae BAL61208.1
BAA84491.1
   
 pierisin-1   Pieris rapae BAL61208.1
BAA84491.1
   
 PR2455   Piromyces rhizinflatus ASF57710.1    
 ORF (fragment)   Plasmopara viticola CCD28161.1    
 ribosome inactivating protein RIPt   Polygonatum multiflorum AAF37219.1 Q9M653  
 ribosome inactivating protein RIPt   Polygonatum multiflorum AAF37219.1 Q9M653  
 ribosome inactivating protein RIPm   Polygonatum multiflorum AAF37218.1 Q9M654  
 ribosome inactivating protein RIPm   Polygonatum multiflorum AAF37218.1 Q9M654  
 lectin (Psl1b)   Polyporus squamosus BAC87876.1 Q75WT8  
 lectin (Psl1a)   Polyporus squamosus BAC87875.1 Q75WT9 3PHZ[A,B]
5MUA[A,B]
 lectin   Polyporus umbellatus L1 ANC28063.1    
 DKFZp469B1122   Pongo abelii CAH89461.1 Q5RFJ6  
 DKFZp469L0611   Pongo abelii CAH89838.1 Q5REG9  
 polypeptide N-acetilgalactosaminyltransferase 2, partial (Galnt2)   Procambarus clarkii Pc02122016 AXR98460.1    
 Unknown (protein for IMAGE:7109082)   Rattus norvegicus   B5DF50  
 Polypeptide GalNAc transferase T13   Rattus norvegicus AAQ75749.1
NP_954537.1
Q6UE39  
 GalNT11   Rattus norvegicus AAH62004.1
NP_955425.1
Q6P6V1  
 Unknown (protein for MGC:94136)   Rattus norvegicus AAH79128.1 Q6AYA4  
 Unknown (protein for IMAGE:7317097) (fragment)   Rattus norvegicus AAH91351.1 Q5BJS5  
 pt-GalNAc-T   Rattus norvegicus BAD91088.1 Q5CD99  
 UDP-GalNAc polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3)   Rattus norvegicus BAD93347.1
AAI01887.1
Q58A69  
 UDP-GalNAc polypeptide N-acetylgalactosaminyltransferase-4 (GalNAc-T4)   Rattus norvegicus BAD93348.1
AAI05819.1
Q58A68  
 Polypeptide GalNAc transferase T6 2.4.1.41 Rattus norvegicus AAC99426.1
NP_075215.1
Q9R0C5  
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase T1 (GalNAc-T1;ppGalNAcT1) 2.4.1.41 Rattus norvegicus NP_077349.1
AAC52511.1
Q10473  
 Unknown (protein for MGC:156692)   Rattus norvegicus AAI28746.1 A1A5P1  
 N-acetylgalactosaminyltransferase T5 (Galnt5) 2.4.1.41 Rattus norvegicus AAC69708.1
NP_113984.1
O88422  
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T9 2.4.1.41 Rattus norvegicus AAK54498.1
EDM04502.1
NP_570098.1
Q925R7  
 agglutinin (RSA) (partial)   Rhizoctonia solani 207.84 (AG-1C)     4G9M[A]
4G9N[A,B]
4G9M[B]
 agglutinin (RSA)   Rhizoctonia solani AG-3 AGL80208.1    
 ricin B-chain (RTB)   Ricinus communis AAY06525.1
AAB22582.1
ABC05333.1
ACY38598.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
AFH96941.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
D0VFC4
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 ricin B-chain (RTB)   Ricinus communis AAY06525.1
AAB22582.1
ABC05334.1
ACY38598.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
AFH96941.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
D0VFC4
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 ORF   Saccoglossus kowalevskii AOR07040.1    
 Sakowv30026278mg   Saccoglossus kowalevskii APU50785.1    
 BT072538 (fragment)   Salmo salar ACN60295.1 C0PUL4  
 sialic acid-binding dwarf elder agglutinin / rRNA N-glycosylase (SEA;AR) (partial)   Sambucus ebulus CAQ42478.1 B5WYH8  
 sialic acid-binding dwarf elder agglutinin / rRNA N-glycosylase (SEA;AR) (partial)   Sambucus ebulus CAQ42478.1 B5WYH8  
 ribosome-inactivating protein precursor (EburP)   Sambucus ebulus ATY37423.1    
 ribosome-inactivating protein precursor (EburP)   Sambucus ebulus ATY37423.1    
 dimeric lectin SELld / SEL blo   Sambucus ebulus AAM94880.1 Q7XJA6  
 dimeric lectin SELld / SEL blo   Sambucus ebulus AAM94880.1 Q7XJA6  
 lectin (Llm1)   Sambucus ebulus CAM33270.1 A7WM72  
 lectin (Llm1)   Sambucus ebulus CAM33270.1 A7WM72  
 ebulin 1 / ebulin blo / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus CAC33178.1
AAB27855.1
ABC05335.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ebulin 1 / ebulin blo / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus CAC33178.1
ABC05336.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 lectin (AIVl4)   Sambucus nigra AAL04122.1 Q945S3  
 lectin (AIVl4)   Sambucus nigra AAL04122.1 Q945S3  
 lectin (AIVl3)   Sambucus nigra AAL04121.1 Q93WL1  
 lectin (AIVl3)   Sambucus nigra AAL04121.1 Q93WL1  
 lectin (AIVl2)   Sambucus nigra AAL04120.1 Q93WL1  
 lectin (AIVl2)   Sambucus nigra AAL04120.1 Q93WL1  
 lectin (AIVl1)   Sambucus nigra AAL04119.1 Q945S4  
 lectin (AIVl1)   Sambucus nigra AAL04119.1 Q945S4  
 type 2 ribosome-inactivating protein SNAIf precursor (Lecsnα-iF)   Sambucus nigra AAC49989.1    
 type 2 ribosome-inactivating protein SNAIf precursor (Lecsnα-iF)   Sambucus nigra AAC49989.1    
 ribosome inactivating protein precursor   Sambucus nigra AAC15886.1    
 ribosome inactivating protein precursor   Sambucus nigra AAC15886.1    
 lectin precursor   Sambucus nigra AAC15885.1    
 lectin precursor   Sambucus nigra AAC15885.1    
 dimeric lectin (SNAld)   Sambucus nigra AAN86131.1 Q8GTA6  
 dimeric lectin (SNAld)   Sambucus nigra AAN86131.1 Q8GTA6  
 SSA-B-3A (LecSSA-B-3A)   Sambucus racemosa subsp. sieboldiana BAD93340.1 Q58A89  
 SSA-B-3A (LecSSA-B-3A)   Sambucus racemosa subsp. sieboldiana BAD93340.1 Q58A89  
 SSA-B-3B (LecSSA-B-3B)   Sambucus racemosa subsp. sieboldiana BAD93341.1 Q58A88  
 SSA-B-3B (LecSSA-B-3B)   Sambucus racemosa subsp. sieboldiana BAD93341.1 Q58A88  
 SSA-B-3C (LecSSA-B-3C)   Sambucus racemosa subsp. sieboldiana BAD93342.1 Q58A87  
 SSA-B-3C (LecSSA-B-3C)   Sambucus racemosa subsp. sieboldiana BAD93342.1 Q58A87  
 SSA-B-4 (LecSSA-B-4)   Sambucus racemosa subsp. sieboldiana BAD93343.1 Q58A86  
 SSA-B-4 (LecSSA-B-4)   Sambucus racemosa subsp. sieboldiana BAD93343.1 Q58A86  
 polypeptide GalNAc transferase 6 (Pgant6)   Schistosoma japonicum CAX73827.1    
 polypeptide GalNAc transferase 6 (Pgant6)   Schistosoma japonicum CAX73828.1    
 ORF   Schistosoma japonicum AAW26230.1 Q5DD76  
 SJCHGC04837 (fragment)   Schistosoma japonicum AAX27174.2 Q5BZK1  
 Smp_159490   Schistosoma mansoni Puerto Rico CAZ34341.1
CCD81426.1
C4QFV6  
 sscle_02g015110   Sclerotinia sclerotiorum 1980 UF-70 APA06741.1    
 SMAX5B_019945   Scophthalmus maximus AWO98632.1    
 SMAX5B_018821 (fragment)   Scophthalmus maximus AWP06544.1    
 SMAX5B_004952   Scophthalmus maximus AWP06361.1    
 SMAX5B_017077   Scophthalmus maximus AWO99563.1    
 SMAX5B_019945 (fragment)   Scophthalmus maximus AWO98631.1    
 SMAX5B_018821 (fragment)   Scophthalmus maximus AWP06545.1    
 SMAX5B_016774   Scophthalmus maximus AWO99562.1    
 SMAX5B_010583   Scophthalmus maximus AWO97443.1    
 SMAX5B_011898   Scophthalmus maximus AWO96649.1    
 SMAX5B_012571   Scophthalmus maximus AWP01554.1    
 SMAX5B_012457   Scophthalmus maximus AWP01747.1    
 SMAX5B_014687   Scophthalmus maximus AWP09642.1    
 SMAX5B_008986   Scophthalmus maximus AWP16066.1    
 SMAX5B_015375   Scophthalmus maximus AWP08968.1    
 SMAX5B_017850   Scophthalmus maximus AWP08821.1    
 SMAX5B_018525   Scophthalmus maximus AWP13071.1    
 SMAX5B_014687 (fragment)   Scophthalmus maximus AWP09643.1
AXN70195.1
   
 SMAX5B_000117   Scophthalmus maximus AWP20412.1    
 SMAX5B_014687 (fragment)   Scophthalmus maximus AWP09644.1    
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