Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5533); Uniprot accession (902); PDB accession (143); 3D entries (56); cryst (1)
All (5278) Archaea (18) Bacteria (4665) Eukaryota (558) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 lectin (Psl1b)   Polyporus squamosus BAC87876.1 Q75WT8  
 lectin (Psl1a)   Polyporus squamosus BAC87875.1 Q75WT9 3PHZ[A,B]
5MUA[A,B]
 lectin   Polyporus umbellatus L1 ANC28063.1    
 DKFZp469B1122   Pongo abelii CAH89461.1 Q5RFJ6  
 DKFZp469L0611   Pongo abelii CAH89838.1 Q5REG9  
 Unknown (protein for IMAGE:7109082)   Rattus norvegicus   B5DF50  
 Polypeptide GalNAc transferase T13   Rattus norvegicus AAQ75749.1
NP_954537.1
Q6UE39  
 GalNT11   Rattus norvegicus AAH62004.1
NP_955425.1
Q6P6V1  
 Unknown (protein for MGC:94136)   Rattus norvegicus AAH79128.1 Q6AYA4  
 Unknown (protein for IMAGE:7317097) (fragment)   Rattus norvegicus AAH91351.1 Q5BJS5  
 pt-GalNAc-T   Rattus norvegicus BAD91088.1 Q5CD99  
 UDP-GalNAc polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3)   Rattus norvegicus BAD93347.1
AAI01887.1
Q58A69  
 UDP-GalNAc polypeptide N-acetylgalactosaminyltransferase-4 (GalNAc-T4)   Rattus norvegicus BAD93348.1
AAI05819.1
Q58A68  
 Polypeptide GalNAc transferase T6 2.4.1.41 Rattus norvegicus AAC99426.1
NP_075215.1
Q9R0C5  
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase T1 (GalNAc-T1;ppGalNAcT1) 2.4.1.41 Rattus norvegicus NP_077349.1
AAC52511.1
Q10473  
 Unknown (protein for MGC:156692)   Rattus norvegicus AAI28746.1 A1A5P1  
 N-acetylgalactosaminyltransferase T5 (Galnt5) 2.4.1.41 Rattus norvegicus AAC69708.1
NP_113984.1
O88422  
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T9 2.4.1.41 Rattus norvegicus AAK54498.1
EDM04502.1
NP_570098.1
Q925R7  
 agglutinin (RSA) (partial)   Rhizoctonia solani 207.84 (AG-1C)     4G9M[A]
4G9N[A,B]
4G9M[B]
 agglutinin (RSA)   Rhizoctonia solani AG-3 AGL80208.1    
 ricin B-chain (RTB)   Ricinus communis AAY06525.1
AAB22582.1
ABC05333.1
ACY38598.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
AFH96941.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
D0VFC4
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 ricin B-chain (RTB)   Ricinus communis AAY06525.1
AAB22582.1
ABC05334.1
ACY38598.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
AFH96941.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
D0VFC4
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 ORF   Saccoglossus kowalevskii AOR07040.1    
 Sakowv30026278mg   Saccoglossus kowalevskii APU50785.1    
 BT072538 (fragment)   Salmo salar ACN60295.1 C0PUL4  
 sialic acid-binding dwarf elder agglutinin / rRNA N-glycosylase (SEA;AR) (partial)   Sambucus ebulus CAQ42478.1 B5WYH8  
 sialic acid-binding dwarf elder agglutinin / rRNA N-glycosylase (SEA;AR) (partial)   Sambucus ebulus CAQ42478.1 B5WYH8  
 dimeric lectin SELld / SEL blo   Sambucus ebulus AAM94880.1 Q7XJA6  
 dimeric lectin SELld / SEL blo   Sambucus ebulus AAM94880.1 Q7XJA6  
 lectin (Llm1)   Sambucus ebulus CAM33270.1 A7WM72  
 lectin (Llm1)   Sambucus ebulus CAM33270.1 A7WM72  
 ebulin 1 / ebulin blo / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus CAC33178.1
AAB27855.1
ABC05335.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ebulin 1 / ebulin blo / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus CAC33178.1
ABC05336.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 lectin (AIVl4)   Sambucus nigra AAL04122.1 Q945S3  
 lectin (AIVl4)   Sambucus nigra AAL04122.1 Q945S3  
 lectin (AIVl3)   Sambucus nigra AAL04121.1 Q93WL1  
 lectin (AIVl3)   Sambucus nigra AAL04121.1 Q93WL1  
 lectin (AIVl2)   Sambucus nigra AAL04120.1 Q93WL1  
 lectin (AIVl2)   Sambucus nigra AAL04120.1 Q93WL1  
 lectin (AIVl1)   Sambucus nigra AAL04119.1 Q945S4  
 lectin (AIVl1)   Sambucus nigra AAL04119.1 Q945S4  
 type 2 ribosome-inactivating protein SNAIf precursor (Lecsnα-iF)   Sambucus nigra AAC49989.1    
 type 2 ribosome-inactivating protein SNAIf precursor (Lecsnα-iF)   Sambucus nigra AAC49989.1    
 ribosome inactivating protein precursor   Sambucus nigra AAC15886.1    
 ribosome inactivating protein precursor   Sambucus nigra AAC15886.1    
 lectin precursor   Sambucus nigra AAC15885.1    
 lectin precursor   Sambucus nigra AAC15885.1    
 dimeric lectin (SNAld)   Sambucus nigra AAN86131.1 Q8GTA6  
 dimeric lectin (SNAld)   Sambucus nigra AAN86131.1 Q8GTA6  
 SSA-B-3A (LecSSA-B-3A)   Sambucus racemosa subsp. sieboldiana BAD93340.1 Q58A89  
 SSA-B-3A (LecSSA-B-3A)   Sambucus racemosa subsp. sieboldiana BAD93340.1 Q58A89  
 SSA-B-3B (LecSSA-B-3B)   Sambucus racemosa subsp. sieboldiana BAD93341.1 Q58A88  
 SSA-B-3B (LecSSA-B-3B)   Sambucus racemosa subsp. sieboldiana BAD93341.1 Q58A88  
 SSA-B-3C (LecSSA-B-3C)   Sambucus racemosa subsp. sieboldiana BAD93342.1 Q58A87  
 SSA-B-3C (LecSSA-B-3C)   Sambucus racemosa subsp. sieboldiana BAD93342.1 Q58A87  
 SSA-B-4 (LecSSA-B-4)   Sambucus racemosa subsp. sieboldiana BAD93343.1 Q58A86  
 SSA-B-4 (LecSSA-B-4)   Sambucus racemosa subsp. sieboldiana BAD93343.1 Q58A86  
 polypeptide GalNAc transferase 6 (Pgant6)   Schistosoma japonicum CAX73827.1    
 polypeptide GalNAc transferase 6 (Pgant6)   Schistosoma japonicum CAX73828.1    
 ORF   Schistosoma japonicum AAW26230.1 Q5DD76  
 SJCHGC04837 (fragment)   Schistosoma japonicum AAX27174.2 Q5BZK1  
 Smp_159490   Schistosoma mansoni Puerto Rico CAZ34341.1
CCD81426.1
C4QFV6  
 sscle_02g015110   Sclerotinia sclerotiorum 1980 UF-70 APA06741.1    
 PIIN_01243   Serendipita indica DSM 11827 CCA67412.1    
 PIIN_04393   Serendipita indica DSM 11827 CCA70455.1    
 PIIN_08292   Serendipita indica DSM 11827 CCA74339.1    
 PIIN_01237   Serendipita indica DSM 11827 CCA67406.1    
 PIIN_09434   Serendipita indica DSM 11827 CCA75451.1    
 N-acetylgalactosaminyltransferase (fragment)   Simulium nigrimanum ACZ28391.1 D1FQD6  
 SRAE_1000283400   Strongyloides ratti ED321 Heterogonic CEF64581.1    
 SRAE_2000050400 (fragment)   Strongyloides ratti ED321 Heterogonic CEF65829.1    
 SRAE_X000124600   Strongyloides ratti ED321 Heterogonic CEF59498.1    
 SRAE_2000348700   Strongyloides ratti ED321 Heterogonic CEF68832.1    
 SRAE_2000233200   Strongyloides ratti ED321 Heterogonic CEF67671.1    
 SRAE_2000174000   Strongyloides ratti ED321 Heterogonic CEF67075.1    
 SRAE_2000031600   Strongyloides ratti ED321 Heterogonic CEF65639.1    
 SRAE_0000017900   Strongyloides ratti ED321 Heterogonic CEF61049.1    
 polypeptide N-acetylgalactosaminyltransferase T1 2.4.1.41 Sus scrofa BAA12800.1 Q29121  
 clotting factor G α-subunit   Tachypleus tridentatus BAA04044.1
ACC16493.1
CAL49866.1
Q27082  
 R-type lectin   Tenebrio molitor CCV65019.1    
 MYCTH_89958   Thermothelomyces thermophila ATCC 42464 AEO61028.1    
 THITE_118864   Thielavia terrestris NRRL 8126 XP_003652847.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55423.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55485.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55485.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55518.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55519.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55540.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55540.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55545.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55545.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55595.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55598.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55598.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55614.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55619.1    
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