Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 polypeptide N-acetylgalactosaminyltransferase 11 (Galnt11)   Macaca mulatta AFE64897.1
AFH29119.1
AFI34806.1
   
 ORF   Macaca mulatta AFE65581.1
AFI37066.1
   
 polypeptide N-acetylgalactosaminyltransferase 13 (Galnt13)   Macaca mulatta AFE63516.1    
 ORF   Macaca mulatta AFE79672.1
AFE79673.1
AFI38000.1
AFI38001.1
AFI38002.1
   
 polypeptide N-acetylgalactosaminyltransferase 1 (Galnt1)   Macaca mulatta AFE63996.1
AFH29149.1
AFI34814.1
   
 ORF   Macaca mulatta AFE65281.1    
 polypeptide N-acetylgalactosaminyltransferase 6 (Galnt6)   Macaca mulatta AFE76496.1    
 polypeptide N-acetylgalactosaminyltransferase 12, partial (Galnt12) (fragment)   Macaca mulatta AFE69515.1    
 polypeptide N-acetylgalactosaminyltransferase 14 isoform 1, partial (Galnt14) (fragment)   Macaca mulatta AFE70915.1    
 polypeptide N-acetylgalactosaminyltransferase 2 precursor, partial (Galnt2) (fragment)   Macaca mulatta AFE71315.1    
 polypeptide N-acetylgalactosaminyltransferase 10, partial (Galnt10) (fragment)   Macaca mulatta AFE71974.1    
 polypeptide N-acetylgalactosaminyltransferase 3, partial (Galnt3) (fragment)   Macaca mulatta AFE75134.1    
 ORF   Macaca mulatta AFE76600.1
AFE76601.1
AFE76602.1
AFE76603.1
   
 ORF (fragment)   Macaca mulatta AFE74773.1    
 N-acetylgalactosaminyltransferase 7 (Galnt7)   Macaca mulatta AFH29217.1    
 polypeptide N-acetylgalactosaminyltransferase 2 (Galnt2)   Macaca mulatta AFI34524.1
AFJ70890.1
   
 lectin (MPL)   Macrolepiota procera AEE98238.1   4ION[A,B]
4IYB[A,B]
4IZX[A]
4J2S[A]
 agglutinin (MOA)   Marasmius oreades AAL47680.1
ABC05318.1
ABC05319.1
ABC05320.1
ABC05337.1
ABC05339.1
Q8X123 2IHO[A]
3EF2[A,B,C,D]
5D61[A]
5D62[A]
5D63[A]
5MU9[A]
 ORF   Mayetiola destructor ACZ26277.1 D1MLM6  
 galactose-binding type-2 ribosome-inactivating protein / bitter gourd seed lectin (Mcl1;BGSL)   Momordica charantia BAH05018.1 B7X8M2 4Z8S[B]
4Z9W[B]
4ZA3[B]
4ZBV[B]
4ZFU[B]
4ZFW[B]
4ZFY[B]
4ZGR[B]
4ZLB[B]
 galactose-binding type-2 ribosome-inactivating protein / bitter gourd seed lectin (Mcl1;BGSL)   Momordica charantia BAH05018.1 B7X8M2 4Z8S[B]
4Z9W[B]
4ZA3[B]
4ZBV[B]
4ZFU[B]
4ZFW[B]
4ZFY[B]
4ZGR[B]
4ZLB[B]
 GALNT10;GALNT9   Mus musculus AAH60617.1
AAH16585.1
BAC28334.1
BAD21405.1
BAE34806.1
BAE35020.1
CAI24136.1
CAI24811.1
NP_598950.1
Q5SQF9
Q6P9S7
 
 pp-GalNAc-T17   Mus musculus AAH52469.1
AAM62404.1
BAD91810.1
NP_660253.2
Q59J92
Q7TT15
Q7TT15
 
 ORF   Mus musculus BAD91811.1
AAH24988.1
NP_776100.2
Q59J91
Q8K1B9
 
 ORF   Mus musculus AAH35551.1
AAH31829.1
BAC40145.1
NP_765981.1
Q4VC42
Q8C2S1
Q8K2B9
 
 Crybg3 (5031404N19)   Mus musculus AAH43118.1
BAC26878.1
BAE36951.1
NP_777273.1
Q80W49
Q8BMQ9
 
 ORF   Mus musculus CAM46111.1
AAH42709.1
CAX15536.1
Q811L3  
 UDP-GalNAc: polypeptide α-N-acetylgalactosaminyltransferase T1 (GalNAc-T1;ppGalNAcTase-1;Galnt1) 2.4.1.41 Mus musculus AAB58477.1
AAH56215.1
AAH90962.1
BAE28617.1
NP_038842.2
O08912
O08912
1XHB[A]
 Polypeptide GalNAc transferase T3 (GALNT3) 2.4.1.41 Mus musculus AAB09579.1
AAH43331.1
BAE22551.1
CAM20333.1
CAM21878.1
NP_056551.1
P70419
P70419
 
 Polypeptide GalNAc transferase T4 2.4.1.41 Mus musculus AAB58301.1
AAH57882.1
ABA38430.1
BAC28317.1
BAE28303.1
BAE31844.1
NP_056552.1
O08832  
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase 16 (ppGalNAc-T16)   Mus musculus BAA97985.1
AAI10635.1
AAI25016.1
BAD32383.1
BAD52071.1
BAE23810.1
Q9JJ61  
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7 (Galnt7) 2.4.1.41 Mus musculus AAK37549.1
AAH07484.1
AAH49907.1
AAH52461.1
BAC28284.1
BAC29461.1
BAE30388.1
BAE30662.1
BAE31034.1
BAE31754.1
NP_653332.2
Q80VA0
Q80VA0
 
 polypeptide N-acetylgalactosaminyltransferase T2 (Galnt2) 2.4.1.41 Mus musculus AAK37548.1
AAH07172.1
AAH53063.1
AAH59818.1
BAC32790.1
BAE26246.1
BAE30483.1
NP_644678.1
Q6PB93  
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase GalNT11 2.4.1.41 Mus musculus AAH11428.1
AAH21504.1
AAH34185.1
AAH36143.1
AAH36145.1
AAQ06668.1
BAC40096.1
BAE36442.1
CAC79626.1
Q921L8
Q921L8
 
 UDP-GlcNAc: polypeptide N-acetylgalactosaminyltransferase 20   Mus musculus C57BL/6 ADP69005.1 E5D8G1  
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase 12 (pp-GalNAc-T12)   Mus musculus C57BL/6J BAC31179.1
AAH56425.1
BAC28401.1
BAD52068.1
BAE33836.1
CAM21411.1
CAM21413.1
NP_766281.1
Q60GT3
Q8BGT9
 
 UDP-GalNAc:polypeptide α-GalNAc-transferase (Galnt13)   Mus musculus C57BL/6J BAC29981.1
AAI31652.1
AAI31653.1
BAC32353.1
BAC54546.1
CAM19821.1
CAM19822.1
CAM20254.1
CAM20255.1
CAM21811.1
CAM21812.1
CAM22167.1
CAM22168.1
NP_766618.2
A2RRI8
B1AY78
Q8CF93
 
 ppGaNTase-T5   Mus musculus C57BL/6J BAC26396.1
AAI16333.1
CAM18783.1
CAM24473.1
NP_766443.1
Q8C102  
 Unknown (protein for MGC:63144) (fragment)   Mus musculus C57BL/6J BAE42509.1
AAH54061.1
NP_938048.1
Q3TB05
Q7TQL0
 
 Polypeptide GalNAc transferase T6 2.4.1.41 Mus musculus C57BL/6J BAC33618.1
AAI19325.1
AAI19327.1
BAC25984.1
BAE32989.1
BAE35316.1
CAB55352.1
NP_766039.1
Q0VE84
Q8C7U7
Q8C7U7
 
 UDP-GalNAc: polypeptide α-N-acetylgalactosaminyltransferase 15 (pp-GalNAc-T15)   Mus musculus C57BL/6J BAB31741.1
AAI33712.1
BAD52070.1
A3KN88
Q9D2N8
 
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase 14 (pp-GalNAc-T14)   Mus musculus C57BL/6J BAC37208.1
AAI17801.1
BAD52069.1
Q8BVG5
Q8BVG5
 
 ORF   Musca domestica ALHF AFP59102.1    
 ORF   Musca domestica ALHF AFP59656.1    
 ORF (probable fragment)   Musca domestica ALHF AFP62687.1    
 ORF   Musca domestica ALHF AFP63273.1    
 ORF   Musca domestica ALHF AFP59825.1    
 ORF (fragment)   Musca domestica ALHF AFP63468.1    
 ORF   Mustela putorius furo AER98900.1    
 absent in melanoma 1, partial (fragment)   Mustela putorius furo AER93949.1    
 Absent in melanoma 1 protein, partial (fragment)   Mustela putorius furo AER93950.1    
 β-γ- crystallin domain containing 3, partial (fragment)   Mustela putorius furo AER96737.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1, partial (fragment)   Mustela putorius furo AER98881.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10, partial (fragment)   Mustela putorius furo AER98883.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11   Mustela putorius furo AER98884.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13, partial (fragment)   Mustela putorius furo AER98887.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3, partial (fragment)   Mustela putorius furo AER98891.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6, partial (fragment)   Mustela putorius furo AER98893.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7, partial (fragment)   Mustela putorius furo AER98895.1    
 UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12, partial (fragment)   Mustela putorius furo AER98885.1    
 ORF, partial (fragment)   Mustela putorius furo AER98889.1    
 ORF (fragment)   Mustela putorius furo AER98898.1    
 ORF (fragment)   Mustela putorius furo AER98899.1    
 NF2523, partial (fragment)   Neocallimastix frontalis ASF57709.1    
 NF2152   Neocallimastix frontalis ASF57707.1    
 NF2215   Neocallimastix frontalis ASF57708.1    
 W5-CAT7 (fragment)   Neocallimastix patriciarum W5 AEX92721.1    
 NCLIV_010830   Neospora caninum Liverpool CBZ50615.1    
 NCLIV_067480   Neospora caninum Liverpool CBZ56323.1    
 NCU07050   Neurospora crassa OR74A EAA30896.1    
 NCU07050.1   Neurospora crassa OR74A XP_327336.1 Q7S5U7  
 ORF (fragment)   Pan troglodytes BAK63143.1    
 ORF (fragment)   Pan troglodytes BAK63908.1    
 ribosome-inactivating protein (RiP)   Panax ginseng ABG76785.1 Q0PVD2  
 ORF (fragment)   Papilio xuthus BAM18785.1    
 pierisin-2 / pierisin-B   Pieris brassicae BAB13774.1 Q9GV36  
 pierisin-2 / pierisin-B   Pieris brassicae BAB13774.1 Q9GV36  
 pierisin-2 / pierisin-B   Pieris brassicae BAB13774.1 Q9GV36  
 pierisin-5   Pieris canidia AJF36051.1    
 pierisin-5   Pieris canidia AJF36051.1    
 pierisin-5   Pieris canidia AJF36051.1    
 pierisin-5   Pieris canidia AJF36051.1    
 pierisin-3   Pieris melete BAH96562.1 C6L2F5  
 pierisin-3   Pieris melete BAH96562.1 C6L2F5  
 pierisin-3   Pieris melete BAH96562.1 C6L2F5  
 pierisin-6   Pieris napi AJF36052.1    
 pierisin-6   Pieris napi AJF36052.1    
 pierisin-6   Pieris napi AJF36052.1    
 pierisin-1b   Pieris rapae ADU33873.1    
 pierisin-1b   Pieris rapae ADU33873.1    
 pierisin-1   Pieris rapae BAL61208.1
BAA84491.1
   
 pierisin-1   Pieris rapae BAL61208.1
BAA84491.1
   
 pierisin-1   Pieris rapae BAL61208.1
BAA84491.1
   
 PR2455   Piromyces rhizinflatus ASF57710.1    
 ORF (fragment)   Plasmopara viticola CCD28161.1    
 ribosome inactivating protein RIPt   Polygonatum multiflorum AAF37219.1 Q9M653  
 ribosome inactivating protein RIPt   Polygonatum multiflorum AAF37219.1 Q9M653  
 ribosome inactivating protein RIPm   Polygonatum multiflorum AAF37218.1 Q9M654  
 ribosome inactivating protein RIPm   Polygonatum multiflorum AAF37218.1 Q9M654  
 lectin (Psl1b)   Polyporus squamosus BAC87876.1 Q75WT8  
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