Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Unknown (protein for MGC:153274)   Danio rerio AAI24298.1 Q08CC3  
 CH211-126H20.1-001 (fragment)   Danio rerio CAM13157.1
CAM13157.2
CAM16501.1
A2CEE9  
 DKEY-162B3.1-001   Danio rerio CAQ15398.1 B0V0U4  
 ORF (MGC:194153 IMAGE:9037940) LOC561084   Danio rerio AAI62724.1 B3DHD4  
 CupC   Dictyostelium discoideum AAP40291.1 Q7Z202  
 CupF   Dictyostelium discoideum AAP40294.1 Q7Z1I0  
 CupA   Dictyostelium discoideum AAP40296.1 Q55FW5
Q7Z1Z8
 
 CupB   Dictyostelium discoideum AAP40290.1 Q7Z203  
 CupD   Dictyostelium discoideum AAP40292.1 Q54BF5  
 CupE   Dictyostelium discoideum AAP40293.1 Q7Z200  
 CupG   Dictyostelium discoideum AAP40295.1 Q7Z1Z9  
 Dbus_chr3Lg1910   Drosophila busckii ALC44744.1    
 Dbus_chr2Rg1559   Drosophila busckii ALC41980.1    
 Dbus_chr2Lg323   Drosophila busckii ALC38238.1    
 Dbus_chr2Lg2024   Drosophila busckii ALC39939.1    
 Dbus_chr2Lg1331   Drosophila busckii ALC39246.1    
 Dbus_chr3Lg455   Drosophila busckii ALC43289.1    
 Dbus_chr3Rg2797   Drosophila busckii ALC48047.1    
 Dbus_chr3Lg1844   Drosophila busckii ALC44678.1    
 Dbus_chr2Rg1660 (fragment)   Drosophila busckii ALC42081.1    
 Dbus_chr2Rg834   Drosophila busckii ALC41255.1    
 Dbus_chrXg1854   Drosophila busckii ALC49998.1    
 polypeptide N-acetylgalactosaminyltransferase T4 (CG31956;AT25481p1) 2.4.1.41 Drosophila melanogaster AAN10370.1
AAN10370.2
AAN75751.1
AAQ56701.1
ACL82986.1
AER27632.1
NP_722910.1
B7Z006
Q8IA42
Q8IA42
 
 polypeptide N-acetylgalactosaminyltransferase T3 (CG4445) 2.4.1.41 Drosophila melanogaster AAD38630.1
AAF59298.1
NP_610256.1
Q9Y117  
  polypeptide N-acetylgalactosaminyltransferase T35A / l(2)35Aa (Pgant35A;CG7480) 2.4.1.41 Drosophila melanogaster AAF44871.1
AAF53391.1
AAK66862.1
AAM62405.1
AAM62406.1
AEG66944.1
NP_652069.2
F5XVG5
Q8MVS5
Q8MVS5
 
 polypeptide N-acetylgalactosaminyltransferase T7 (CG6394) 2.4.1.41 Drosophila melanogaster AAF48851.1
AAM62412.1
AAN09470.1
AAQ56704.1
AAV37008.1
AHN59876.1
NP_573301.2
NP_728178.1
Q8MV48
Q8MV48
 
 polypeptide N-acetylgalactosaminyltransferase T6 (CG2103) 2.4.1.41 Drosophila melanogaster AAF47689.1
AAF47690.1
AAL29177.1
AAQ56703.1
AGB94037.1
AGV77152.1
NP_647749.2
NP_728779.1
Q6WV16  
 polypeptide N-acetylgalactosaminyltransferase T8 (CG7297) 2.4.1.41 Drosophila melanogaster AAF49587.1
AAL48588.1
NP_648800.1
Q9VUT6  
 CG7579   Drosophila melanogaster AAO13781.1
AAF49588.1
NP_648799.1
Q8IA41
Q8IA41
 
 CG7304   Drosophila melanogaster AAF49589.2
AAN75749.1
AAS64999.1
NP_648798.1
Q8IA44
Q8IA44
 
 CG10000   Drosophila melanogaster AAM29489.1
AAF56810.1
AAF56810.2
AFD10760.1
NP_651630.2
Q8MYY6
Q8MYY6
 
 CG31776   Drosophila melanogaster AAN75750.1
AAF51101.2
AAF51101.3
AAY55243.1
NP_722909.1
Q8IA43
Q8IA43
 
 polypeptide N-acetylgalactosaminyltransferase T2 (CG3254) 2.4.1.41 Drosophila melanogaster AAQ22499.1
AAF51113.2
AAF51113.3
AAQ56700.1
AAS64620.1
AAS64620.2
NP_608773.1
Q6WV19  
  polypeptide N-acetylgalactosaminyltransferase T5 (CG31651) 2.4.1.41 Drosophila melanogaster AAF52218.2
AAL25377.1
AAQ56702.1
ABI31292.1
NP_608906.2
Q6WV17  
 CG30463   Drosophila melanogaster AAF57964.2
AAF57964.3
AAF57966.2
AAM51988.1
ABV53822.1
ABV53823.1
ABV53824.1
NP_725602.1
NP_725603.1
Q8MRC9
Q8MRC9
 
 polypeptide N-acetylgalactosaminyltransferase T1 (CG8182) 2.4.1.41 Drosophila melanogaster AAG13184.1
AAF58130.1
AAM29416.1
AAM70974.1
AAQ56699.1
NP_611043.1
NP_725472.1
Q6WV20  
 ORF   Entamoeba invadens IP1 BAN40484.1
BAN40537.1
BAN40552.1
BAN40861.1
BAN41074.1
BAN41311.1
BAN41790.1
BAN42004.1
BAN42029.1
   
 ORF   Entamoeba invadens IP1 BAN41570.1    
 ORF   Entamoeba invadens IP1 BAN42519.1    
 xylanase (XynA) (partial)   Epidinium caudatum BAC57894.1 Q86S91  
 ORF (fragment)   Equus caballus AEH58447.1    
 ORF (fragment)   Equus caballus AEP99605.1    
 ORF (fragment)   Equus caballus AEQ00388.1    
 ORF (fragment)   Equus caballus AEQ00435.1    
 ORF   Euphorbia tirucalli BAV60251.1    
 ORF   Euphorbia tirucalli BAV60251.1    
 FFUJ_09220   Fusarium fujikuroi IMI 58289 CCT73945.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF84120.1    
 FGRAMPH1_01T15527   Fusarium graminearum PH-1 SCB65972.1    
 RCJMB04_17f16   Gallus gallus CAG32082.1 Q5ZJL1  
 RCJMB04_1b1   Gallus gallus CAH65007.1 Q5F4C7  
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15;GALNTL2;GalNAc-T15) 2.4.1.41 Homo sapiens AAK63127.1
AAE72285.1
AAE73125.1
AAH14789.1
AAH30625.1
AAQ88808.1
ABA31473.1
ABA36473.1
ABA38055.1
ABA68732.1
ABA69735.1
ABA70117.1
ABA70240.1
ABC04061.1
ABC16096.1
ABE23551.1
ABE26114.1
ABE26387.1
ABH64624.1
ABH64747.1
ABH64904.1
ABH66133.1
ABH70952.1
ABH71075.1
ABH72589.1
ABH75704.1
ABH99489.1
ABI02594.1
ABI07395.1
ABI11043.1
ABI12263.1
ABJ19428.1
ABJ34423.1
ABL21883.1
ABX94001.1
ABX96294.1
ABX96604.1
ABY05068.1
ABY16007.1
ABY18804.1
ACC22268.1
ACC22839.1
ACC23718.1
ACC32509.1
ACC34084.1
ACE08795.1
ACG89706.1
ACK00002.1
ACM95112.1
ACN08875.1
ACP73867.1
ACS06493.1
ACS08649.1
ACW23860.1
BAD29961.1
BAG52928.1
CAD38585.1
CAD89983.1
CAG32963.1
CAK32357.1
NP_473451.2
F1LIP6
Q8N3T1
 
 Polypeptide GalNAc transferase T13 (contains KIAA1918) 2.4.1.41 Homo sapiens CAD44533.2
AAI01032.1
AAI01034.1
AAI01035.1
ACC22253.1
AHW56483.1
API81388.1
API81389.1
API81392.1
BAC54545.1
BAG54747.1
CAG32964.1
NP_443149.2
Q68VI8
Q8IUC8
 
 pp-GalNAc-transferase 20 (GALNT20)   Homo sapiens AAM62306.1
AAH67524.1
AAH67525.1
AAH69624.1
AAH69628.1
AAH69636.1
AAH69645.1
AAH69997.1
ABA66799.1
BAD93180.1
BAF82725.1
BAG52344.1
BAG52964.1
BAG54282.1
CAF25037.1
NP_071924.1
Q2L4S5
Q6IS24
 
 LOC131544   Homo sapiens NP_705833.2
AAH36247.1
AAH50394.1
AAP97687.1
ABA66697.1
BAC03608.1
BAC05338.1
CAD38587.1
CAF15533.1
CAH18168.1
XP_059525.2
Q68DQ2
Q7Z4R9
Q86VD0
Q8N262
Q8N7F1
Q8NDQ8
 
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 14 (GalNT14;pp-GalNAc-T14) 2.4.1.41 Homo sapiens BAC56889.1
AAH06269.1
AAH06269.2
AAH10659.1
AAQ89118.1
AAX88899.1
ABA66763.1
ABH82928.1
ABI02314.1
ABI12599.1
ABJ30825.1
ABJ38955.1
ABX91594.1
ABX91870.1
ABX92146.1
ABX92422.1
ABX92698.1
ABX93132.1
ABX93639.1
ABX94373.1
ABX95380.1
ABX95656.1
ABX95932.1
ABY04154.1
ABY04430.1
ABY04706.1
ABY05292.1
ABY16398.1
ABY17890.1
ABY18166.1
ABY18442.1
ACC25543.1
ACC26284.1
ACC36580.1
ACC36856.1
ACE07501.1
ACE09339.1
ACE10551.1
ACJ96114.1
ACN02380.1
ACN06790.1
ACP73505.1
ACP89033.1
ACR88983.1
ACR89535.1
ACW28625.1
BAB14227.1
BAB14795.1
BAC03634.1
BAG53701.1
BAH12861.1
CAA70505.3
CAA70505.4
CAD10224.1
CAD34770.1
CAD44543.1
CAE91230.1
CAE91506.1
NP_078848.2
Q96FL9  
 GalNAc-transferase 18 (GALNT18) aka GalNAc-T15   Homo sapiens AAH60864.1
AAH37341.3
ABE14321.1
BAD93179.1
BAG51470.1
CAF25035.1
NP_940918.1
Q58A54
Q6P9A2
 
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11;ppGalNAcT11;GalNT11) 2.4.1.41 Homo sapiens AAD45821.1
ACC22266.1
BAB15105.1
BAB15338.1
BAG54116.1
BAH12901.1
CAC79625.2
CAC79625.3
CAD38481.1
NP_071370.2
Q8NCW6
Q8NCW6
 
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase T4 (GalNAc-T4;ppGalNAcT4;GALNT4) 2.4.1.41 Homo sapiens AAN94203.1
AAH36390.1
AAN94205.1
BAG35722.1
BAG60038.1
CAA69875.1
NP_003765.1
Q8N4A0
Q8N4A0
 
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase T1 (GalNAc-T1;ppGalNAcT1;GALNT1) 2.4.1.41 Homo sapiens CAA59380.1
AAC50327.1
AAH38440.1
ACC22256.1
BAF85751.1
CAD44535.1
NP_065207.2
Q10472
Q10472
 
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase T2 (GalNAc-T2;ppGalNAcT2;GalNT2; pp-GalNAc-T2) 2.4.1.41 Homo sapiens AAH41120.1
ACC22257.1
ACS13744.1
BAF82737.1
BAH12448.1
BAH13288.1
BAW34839.1
BAW34840.1
CAA59381.1
CAC00585.2
CAI22902.1
CAI23447.1
NP_004472.1
Q10471 2FFU[A]
2FFV[A,B]
4D0T[A,B,C,D,E,F]
4D0Z[A,B,C,D,E,F]
4D11[A,B,C,D,E]
5AJN[A]
5AJO[A]
5AJP[A]
5FV9[A,B,C,D,E,F]
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase T3 (ppGalNacT3;GALNAc-T3;GALNT3) 2.4.1.41 Homo sapiens CAA63371.1
AAI13566.1
AAI13568.1
AAY14678.1
BAG36187.1
CAD44536.1
NP_004473.1
Q14435  
 AIM1L   Homo sapiens CAI15850.2
AAI36871.1
BAC04533.1
CAI15847.1
CAI15850.1
Q8N1P7  
 GlaNAc-T15   Homo sapiens CAG32965.1    
 GD:RP11-294H11.2-001   Homo sapiens CAH72091.1
BAG59543.1
BAG62166.1
CAI21046.1
CAZ39538.1
NP_001615.1
Q9Y4K1  
 UDP-GlcNAc: polypeptide N-acetylgalactosaminyltransferase 17 / 20 (GALNT17)   Homo sapiens AAH47551.1
ADP69004.1
CAF25036.1
NP_001030017.1
E5D8G0
Q49A17
 
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase T6 (GalNAc-T6) 2.4.1.41 Homo sapiens NP_009141.2
AAH35822.2
AAI14506.1
BAB15297.1
BAC11118.1
BAG52560.1
BAG59418.1
BAJ10977.1
CAA69876.1
CAF85889.1
CAM83953.1
CAM83954.1
NP_009141.1
D7UNW5
Q8NCL4
Q8NCL4
 
 GALNT16   Homo sapiens BAF98739.1
AAH36812.1
AAH36812.2
AAH98578.1
AAI22546.1
ACC22271.1
BAA86444.1
BAD93178.1
BAF82434.1
BAG61521.1
CAD44534.1
CAG32966.1
EAW80988.1
NP_065743.1
Q68VJ8
Q8N428
Q8N428
 
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13 (GALNT13) 2.4.1.41 Homo sapiens AAI01033.1
API81394.1
Q08ER7
Q8IUC8
 
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5 (ppGalNacT5;GALNT5) 2.4.1.41 Homo sapiens AAP34404.1
AAF15313.1
AAI42677.1
ACC22260.1
BAF84843.1
CAB65104.1
CAD44537.1
NP_055383.1
XP_050509.1
A5PKZ1
Q7Z7M9
Q7Z7M9
 
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7 (GALNT7;GALNAC-T7;GalNAcT7) 2.4.1.41 Homo sapiens CAB60270.1
AAH35303.1
AAH46129.1
AAH47468.1
BAG52155.1
CAC39783.1
CAD44538.1
CAI72154.1
NP_059119.1
NP_059119.2
B3KQU3
Q86SF2
Q86SF2
 
 polypeptide GalNAc transferase 8 (GalNAc-T8) 2.4.1.41 Homo sapiens NP_059113.1
CAD44539.1
Q9NY28  
 polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9) 2.4.1.41 Homo sapiens BAB13699.2
AAH69354.1
AAH93817.1
AAH93817.2
AAH93819.1
AAH93819.2
AAM49722.1
AAT18857.1
ABE14200.1
BAG51429.1
BAG51570.1
CAD44540.1
NP_068580.1
Q9HCQ5
Q9HCQ5
 
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 10 (GalNT10;ppGalNAcT10;pp-GalNAc-T10) 2.4.1.41 Homo sapiens CAD44532.1
AAH07224.2
AAH72450.1
AAH98444.1
AAP65372.1
AAP65373.1
AAP65378.1
AAP65379.1
ABA33148.1
ABA33149.1
ABA33154.1
ABA33155.1
BAB14676.1
BAC56890.1
BAG54441.1
CAB46378.1
CAE91109.1
NP_060010.2
NP_938080.1
Q86SR1
Q86SR1
2D7I[A]
2D7R[A]
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 12 (ppGalNAcT12;Galnt12) 2.4.1.41 Homo sapiens BAC07181.1
AAH13945.1
ABA38425.1
BAB15027.1
BAD93346.1
CAC80100.2
CAD44541.1
CAG32962.1
CAI17042.1
NP_078918.3
Q8IXK2
Q8IXK2
 
 ORF   Hypocrella siamensis MTCC 10142 ANH56430.1    
 ORF (Galnt2)   Ictalurus punctatus AHH38789.1    
 ORF (Galnt1)   Ictalurus punctatus AHH39007.1    
 ORF (Galnt13)   Ictalurus punctatus AHH40131.1    
 ORF (Galnt12)   Ictalurus punctatus AHH40601.1    
 ORF (Galnt11)   Ictalurus punctatus AHH42095.1    
 type 2 ribosomal inactivating protein   Jatropha curcas AFK73425.1    
 type 2 ribosomal inactivating protein   Jatropha curcas AFK73425.1    
 LRAMOSA04311   Lichtheimia ramosa CDS12116.1    
 LRAMOSA01149   Lichtheimia ramosa CDS03748.1    
 LRAMOSA09131   Lichtheimia ramosa CDS06603.1    
 LRAMOSA04754   Lichtheimia ramosa CDS12560.1    
 LRAMOSA06808 (fragment)   Lichtheimia ramosa CDS03853.1    
 LRAMOSA06816   Lichtheimia ramosa CDS03861.1    
 LRAMOSA09130   Lichtheimia ramosa CDS06602.1    
 LRAMOSA01512   Lichtheimia ramosa CDS07563.1    
 clotting factor G alpha subunit   Limulus polyphemus BAJ10550.1 D7USH0  
 29-kDa galactose-binding lectin (R-type) (EW29)   Lumbricus terrestris BAA36393.1   2RST[A]
2ZQN[A,B]
2ZQO[A,B]
 ORF (fragment)   Macaca fascicularis BAE01503.1 Q4R5X2  
 unnamed protein product (fragment)   Macaca fascicularis BAE89150.1    
 ORF (fragment)   Macaca fascicularis BAB17281.1 Q9GLZ7  
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase   Macaca fascicularis BAB17277.1 Q9GM01  
 ORF   Macaca fascicularis BAB39313.1 Q9BE81  
 polypeptide N-acetylgalactosaminyltransferase 9 isoform A (Galnt9)   Macaca mulatta AFE78483.1    
 polypeptide N-acetylgalactosaminyltransferase 4 (Galnt4)   Macaca mulatta AFE80645.1    
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