Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5533); Uniprot accession (902); PDB accession (143); 3D entries (56); cryst (1)
All (5278) Archaea (18) Bacteria (4665) Eukaryota (558) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF (protein for MGC:159781)   Bos taurus AAI47930.1 A6QLD9  
 Unknown (protein for MGC:151803)   Bos taurus AAI51594.1 A7YY74  
 Unknown (protein for MGC:159986)   Bos taurus AAI49808.1 A8E4N1  
 glycoside hydrolase family 27 protein (Bofut4_p049070.1)   Botrytis cinerea T4 CCD45889.1    
 ZK688.8 (gly3) 2.4.1.41 Caenorhabditis elegans Bristol N2 AAC13669.1
AAA28224.3
CCD62541.1
NP_498722.1
P34678  
 Y116F11B.12 (Gly-4) 2.4.1.41 Caenorhabditis elegans Bristol N2 AAC13670.1
CAC14394.1
CBA11615.1
NP_507850.1
Q8I136
Q8I136
 
 Y39E4B.12 (Gly-5)   Caenorhabditis elegans Bristol N2 AAC13672.1
AAC13671.1
AAC13673.1
CAB54435.1
CAC42368.1
CAC42369.1
NP_499721.3
NP_499722.2
NP_741277.1
Q95ZJ1
Q95ZJ1
 
 H38K22.5 (Gly-6) 2.4.1.41 Caenorhabditis elegans Bristol N2 AAC13674.1
AAC13675.1
AAC13676.1
CAA19707.1
CAC42317.1
CAC42318.1
NP_001022644.1
O61394  
 Y46H3A.6 (gly-7) 2.4.1.41 Caenorhabditis elegans Bristol N2 CCD70652.1
AAC13677.1
AAF60620.1
NP_503512.1
O61397  
 GLY9 (Y47D3A.23) 2.4.1.41 Caenorhabditis elegans Bristol N2 AAC13679.1
CAB57897.1
CAI46621.1
NP_499451.1
Q9U2C4
Q9U2C4
 
 Y45F10D.3   Caenorhabditis elegans Bristol N2 CAJ76949.1
CAA16378.1
CAA16378.2
NP_502656.1
O45947  
 Y75B8A.9   Caenorhabditis elegans Bristol N2 CAA22098.1
NP_499582.1
Q7K755  
 Y116F11B.m   Caenorhabditis elegans Bristol N2 CAB81981.1    
 ORF   Callorhinchus milii AFO96813.1    
 ORF   Callorhinchus milii AFO96222.1    
 ORF   Callorhinchus milii AFO99002.1    
 ORF   Callorhinchus milii AFO99688.1    
 ORF   Callorhinchus milii AFO99832.1    
 ORF   Callorhinchus milii AFO94698.1    
 ORF   Callorhinchus milii AFO95648.1    
 ORF   Callorhinchus milii AFO95873.1    
 ORF   Callorhinchus milii AFO96002.1    
 ORF   Callorhinchus milii AFO97498.1    
 ORF   Callorhinchus milii AFO98320.1    
 ORF (fragment)   Callorhinchus milii AFP03276.1    
 ORF (fragment)   Callorhinchus milii AFO99200.1    
 ORF   Callorhinchus milii AFO93892.1    
 ORF   Callorhinchus milii AFO95410.1    
 ORF (fragment)   Callorhinchus milii AFO96912.1    
 ORF (fragment)   Callorhinchus milii AFP03046.1    
 ORF   Camellia sinensis ACV60361.2
ADF45509.1
D3GDL1  
 ORF   Camellia sinensis ACV60361.2
ADF45509.1
D3GDL1  
 type 2 ribosome-inactivating protein (Rip2)   Camellia sinensis ADF45510.1 D5LNF6  
 type 2 ribosome-inactivating protein (Rip2)   Camellia sinensis ADF45510.1 D5LNF6  
 type 2 ribosome-inactivating protein precursor (Rip3)   Camellia sinensis ADF45512.1 D5LNF8  
 type 2 ribosome-inactivating protein precursor (Rip3)   Camellia sinensis ADF45512.1 D5LNF8  
 ricin B lectin domain protein II (fragment)   Camellia sinensis AFO70213.1    
 polypeptide N-acetylgalactosaminyltransferase 5 (Galnt5)   Castor fiber ANG60420.1    
 β-γ- crystallin domain containing 3 (Crybg3)   Castor fiber AOY33851.1    
 chrysaoralin   Chrysaora quinquecirrha AOO35152.1    
 chrysaoralin   Chrysaora quinquecirrha AOO35152.1    
 chrysaoralin   Chrysaora quinquecirrha AOO35153.1    
 chrysaoralin   Chrysaora quinquecirrha AOO35153.1    
 type 2 ribosome-inactivating protein   Cinnamomum camphora AET98835.1    
 type 2 ribosome-inactivating protein   Cinnamomum camphora AET98835.1    
 cinnamomin   Cinnamomum camphora AAK82458.1
AAF68978.1
AAF68978.2
AAK82459.1
Q94BW4
Q94BW5
Q9FV22
 
 cinnamomin   Cinnamomum camphora AAK82458.1
AAF68978.1
AAF68978.2
AAK82459.1
Q94BW4
Q94BW5
Q9FV22
 
 carbohydrate binding module (C28) (partial)   Coptotermes formosanus AEW67346.1    
 carbohydrate binding module (C577) (partial)   Coptotermes formosanus AEW67347.1    
 carbohydrate binding module (C2438) (partial)   Coptotermes formosanus AEW67348.1    
 carbohydrate binding module (C5850) (partial)   Coptotermes formosanus AEW67349.1    
 carbohydrate binding module (C6365) (partial)   Coptotermes formosanus AEW67350.1    
 carbohydrate binding module (C7041) (partial)   Coptotermes formosanus AEW67351.1    
 carbohydrate binding module (C7799) (partial)   Coptotermes formosanus AEW67352.1    
 carbohydrate binding module (C9769) (partial)   Coptotermes formosanus AEW67353.1    
 carbohydrate binding module (C11060) (partial)   Coptotermes formosanus AEW67354.1    
 carbohydrate binding module (C11752) (partial)   Coptotermes formosanus AEW67355.1    
 ORF (partial)   Coptotermes formosanus AEW67356.1
AGM32244.1
   
 ricin-type β-trefoil lectin domain-containing protein   Coptotermes formosanus AFZ78852.1    
 ricin-type β-trefoil lectin domain-containing protein   Coptotermes formosanus AFZ78853.1    
 ricin-type β-trefoil lectin domain-containing protein   Coptotermes formosanus AFZ78854.1    
 ORF   Crotalus adamanteus AFJ50722.1    
 ORF   Crotalus adamanteus AFJ50973.1    
 ORF   Crotalus adamanteus AFJ51806.1    
 CGB_A5700W   Cryptococcus gattii WM276 ADV19710.1    
 CGB_J0280W   Cryptococcus gattii WM276 ADV24554.1    
 CGB_A5710W   Cryptococcus gattii WM276 ADV19711.1    
 CGB_A9170W   Cryptococcus gattii WM276 ADV19959.1    
 CNAG_00588   Cryptococcus neoformans var. grubii H99 AFR92718.1    
 CNAG_02694   Cryptococcus neoformans var. grubii H99 AFR93997.1
AGV14186.1
   
 CNAG_04891   Cryptococcus neoformans var. grubii H99 AFR97325.1    
 CNAG_00587   Cryptococcus neoformans var. grubii H99 AFR92717.1    
 CNAG_00799   Cryptococcus neoformans var. grubii H99 AFR92930.1    
 CNK01820   Cryptococcus neoformans var. neoformans JEC21 AAW46144.1 Q5K9I4  
 CNJ03160   Cryptococcus neoformans var. neoformans JEC21 AAW45878.1 Q5KA41  
 CNA05720   Cryptococcus neoformans var. neoformans JEC21 AAW41073.1 Q5KNQ2  
 CNA07770   Cryptococcus neoformans var. neoformans JEC21 AAW41305.1 Q5KN45  
 CNA05710   Cryptococcus neoformans var. neoformans JEC21 AAW41423.1
AAW41423.2
Q5KNQ3  
 GalNAc transferase T1   Cryptosporidium hominis AGL80529.1    
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T3 2.4.1.41 Cryptosporidium parvum AAQ95175.1
AAQ95175.2
Q6TBQ9  
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T1 2.4.1.41 Cryptosporidium parvum AAQ95174.2
AAQ95174.1
Q6TBR0  
 hemolytic lectin (Cel3;CEL-III)   Cucumaria echinata BAC75827.1
BAK19472.1
BAK19473.1
BAK19476.1
Q868M7 1VCL[A,B]
2Z48[A,B]
2Z49[A,B]
3W9T[A,B,C,D,E,F,G]
 hemolytic lectin (Cel3;CEL-III)   Cucumaria echinata BAC75827.1
BAK19472.1
BAK19473.1
BAK19476.1
Q868M7 1VCL[A,B]
2Z48[A,B]
2Z49[A,B]
3W9T[A,B,C,D,E,F,G]
 hemolytic lectin-L1 (Lecl1)   Cucumaria echinata BAK19474.1    
 hemolytic lectin-L1 (Lecl1)   Cucumaria echinata BAK19474.1    
 hemolytic lectin-L2 (Lecl2)   Cucumaria echinata BAK19475.1    
 hemolytic lectin-L2 (Lecl2)   Cucumaria echinata BAK19475.1    
 lectin XSP30   Cucumis sativus BAA88294.1 Q9SLV9  
 lectin XSP30   Cucumis sativus BAA88294.1 Q9SLV9  
 ORF   Cutaneotrichosporon mucoides TIMM 1573 BAB20766.1 Q9HFA9  
 CH211-15E22.3-001   Danio rerio CAX12894.1 B8A6C4  
 MGC:77836   Danio rerio AAH67340.1 Q6NX01  
 CH211-214J24.2-001 (fragment)   Danio rerio CAI11790.1 Q5RHZ9  
 CH211-214J24.3-001 (fragment)   Danio rerio CAI11789.1 Q5RI00  
 CH211-152C2.2-001 (partial)   Danio rerio CAI11619.1 Q5RGY5  
 CH211-147C1.1-001   Danio rerio CAI11605.1 Q5RFV2  
 CH211-147C1.1-001   Danio rerio CAI20718.1 Q5RFV2  
 Unknown (protein for MGC:113219)   Danio rerio AAH90692.1
AAI64662.1
CAK05029.1
Q5CZV4  
 Unknown (protein for MGC:112011)   Danio rerio AAH95642.1
CAX12895.1
Q502M4  
 CH211-9N13.2-001   Danio rerio CAK05028.1 Q1LVP2  
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