Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5533); Uniprot accession (902); PDB accession (143); 3D entries (56); cryst (1)
All (5278) Archaea (18) Bacteria (4665) Eukaryota (558) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | ... | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 SVTN_06080   Streptomyces vietnamensis GIM4.0001 AJF64045.1    
 SVTN_06085   Streptomyces vietnamensis GIM4.0001 AJF64046.1    
 SVTN_31045   Streptomyces vietnamensis GIM4.0001 AJF68143.1    
 SVTN_34285   Streptomyces vietnamensis GIM4.0001 AJF68657.1    
 SVTN_36285   Streptomyces vietnamensis GIM4.0001 AJF68966.1    
 SVTN_36325   Streptomyces vietnamensis GIM4.0001 AJF68970.1    
 SVTN_36830   Streptomyces vietnamensis GIM4.0001 AJF69036.1    
 SVTN_36890   Streptomyces vietnamensis GIM4.0001 AJF69047.1    
 SVTN_00890   Streptomyces vietnamensis GIM4.0001 AJF69426.1    
 SVTN_34290   Streptomyces vietnamensis GIM4.0001 AJF68658.1    
 SVTN_24500   Streptomyces vietnamensis GIM4.0001 AJF67066.1    
 SVTN_22135   Streptomyces vietnamensis GIM4.0001 AJF66664.1    
 B1H20_32835   Streptomyces violaceoruber S21 ARF65675.1    
 B1H20_17995   Streptomyces violaceoruber S21 ARF63069.1    
 B1H20_08840   Streptomyces violaceoruber S21 ARF61501.1    
 B1H20_30620   Streptomyces violaceoruber S21 ARF65283.1    
 B1H20_23565   Streptomyces violaceoruber S21 ARF64021.1    
 B1H20_32840   Streptomyces violaceoruber S21 ARF65676.1    
 Strvi_4277   Streptomyces violaceusniger Tu 4113 AEM83928.1    
 Strvi_5241   Streptomyces violaceusniger Tu 4113 AEM84773.1    
 Strvi_5412   Streptomyces violaceusniger Tu 4113 AEM84937.1    
 Strvi_6116   Streptomyces violaceusniger Tu 4113 AEM85606.1    
 Strvi_6117   Streptomyces violaceusniger Tu 4113 AEM85607.1    
 Strvi_7463   Streptomyces violaceusniger Tu 4113 AEM86815.1    
 SXIM_28450   Streptomyces xiamenensis 318 AKG44229.1    
 SXIM_48910   Streptomyces xiamenensis 318 AKG46275.1    
 SXIM_28440   Streptomyces xiamenensis 318 AKG44228.1    
 SXIM_28460   Streptomyces xiamenensis 318 AKG44230.1    
 SXIM_25620   Streptomyces xiamenensis 318 AKG43946.1    
 SXIM_21330   Streptomyces xiamenensis 318 AKG43517.1    
 SXIM_25760   Streptomyces xiamenensis 318 AKG43960.1    
 SXIM_06510   Streptomyces xiamenensis 318 AKG42035.1    
 SXIM_01540   Streptomyces xiamenensis 318 AKG41538.1    
 Sros_7940   Streptosporangium roseum DSM 43021 ACZ90596.1 D2AUE1  
 Sros_7940   Streptosporangium roseum DSM 43021 ACZ90596.1 D2AUE1  
 Sros_6568   Streptosporangium roseum DSM 43021 ACZ89281.1 D2B257  
 Sros_6745   Streptosporangium roseum DSM 43021 ACZ89454.1 D2B5E9  
 Sros_6745   Streptosporangium roseum DSM 43021 ACZ89454.1 D2B5E9  
 Sros_1212   Streptosporangium roseum DSM 43021 ACZ84210.1 D2BBI7  
 Sros_6915   Streptosporangium roseum DSM 43021 ACZ89618.1 D2B793  
 Sros_0982   Streptosporangium roseum DSM 43021 ACZ83983.1 D2B9H7  
 Sros_3632 (probable fragment)   Streptosporangium roseum DSM 43021 ACZ86563.1 D2AS36  
 TJEJU_3841   Tenacibaculum jejuense KCTC 22618 SNR17473.1    
 TJEJU_1862   Tenacibaculum jejuense KCTC 22618 SNR15568.1    
 TJEJU_3809   Tenacibaculum jejuense KCTC 22618 SNR17442.1    
 TERTU_1485   Teredinibacter turnerae T7901 ACR12221.1 C5BT64  
 TERTU_0766   Teredinibacter turnerae T7901 ACR14229.1 C5BPF4  
 TERTU_3987   Teredinibacter turnerae T7901 ACR11203.1 C5BTR5  
 TERTU_0129   Teredinibacter turnerae T7901 ACS93528.1 C6AQY6  
 Terro_1780   Terriglobus roseus DSM 18391 AFL88076.1    
 AciPR4_2790   Terriglobus saanensis SP1PR4 ADV83563.1 E1N262  
 Theco_1172   Thermobacillus composti KWC4 AGA57343.1    
 Tfu_1643   Thermobifida fusca YX AAZ55678.1 Q47PE1  
 Tbis_2634   Thermobispora bispora DSM 43833 ADG89335.1 D6Y5E0  
 Tbis_0819   Thermobispora bispora DSM 43833 ADG87543.1 D6Y6H1  
 endoxylanase (XynB) (Xyn10A) Thermopolyspora flexuosa DSM43186 / ATCC35864 CAD48748.2
 THII_0786   Thioploca ingrica BAP55083.1    
 ORF   uncultured bacterium ALS90415.1    
 Ricin-type β-trefoil lectin domain protein, partial (fragment)   uncultured bacterium ALS89935.1    
 ricin-type β-trefoil lectin domain protein, partial (fragment)   uncultured bacterium AMP52080.1    
 ORF   uncultured bacterium APO33173.1    
 ORF (fragment)   uncultured bacterium APO33573.1    
 GH62 CBM13, partial (fragment)   uncultured bacterium AQQ75288.1    
 GH16 CBM13   uncultured bacterium AQQ75061.1    
 asmbl_24 (AxhA-2)   uncultured bacterium AHE14830.1    
 ORF   uncultured bacterium A1Q1_fos_1231 AGC71031.1    
 α-galactosidase   uncultured bacterium AZ_40 AKA59483.1    
 ORF   uncultured bacterium Contig1474_n_1484_cl AHF26385.1    
 CKY39_27860   Variovorax boronicumulans J1 ATA56625.1    
 CKY39_02090   Variovorax boronicumulans J1 ATA52147.1    
 VAPA_1c04460   Variovorax paradoxus B4 AGU47576.1    
 Varpa_0387   Variovorax paradoxus EPS ADU34609.1    
 Vapar_0368   Variovorax paradoxus S110 ACS17031.1 C5CYC7  
 CMV30_05905   Verrucomicrobia bacterium HZ-65 ATC63526.1    
 CMV30_03660   Verrucomicrobia bacterium HZ-65 ATC63124.1    
 VbGH5 / VDG1235_3964   Verrucomicrobiae bacterium DG1235 EDY84333.1    
 VAB18032_09875   Verrucosispora maris AB-18-032 AEB43093.1    
 VAB18032_10710   Verrucosispora maris AB-18-032 AEB43260.1    
 VAB18032_10720   Verrucosispora maris AB-18-032 AEB43262.1    
 VAB18032_10890   Verrucosispora maris AB-18-032 AEB43296.1    
 VAB18032_12350   Verrucosispora maris AB-18-032 AEB43584.1    
 VAB18032_13330   Verrucosispora maris AB-18-032 AEB43778.1    
 VAB18032_13725   Verrucosispora maris AB-18-032 AEB43857.1    
 VAB18032_17620   Verrucosispora maris AB-18-032 AEB44626.1    
 VAB18032_18270   Verrucosispora maris AB-18-032 AEB44756.1    
 VAB18032_18310   Verrucosispora maris AB-18-032 AEB44764.1    
 VAB18032_18495   Verrucosispora maris AB-18-032 AEB44801.1    
 VAB18032_18515   Verrucosispora maris AB-18-032 AEB44805.1    
 VAB18032_19530   Verrucosispora maris AB-18-032 AEB45008.1    
 VAB18032_19575   Verrucosispora maris AB-18-032 AEB45017.1    
 VAB18032_19585   Verrucosispora maris AB-18-032 AEB45019.1    
 VAB18032_20140   Verrucosispora maris AB-18-032 AEB45130.1    
 VAB18032_24155   Verrucosispora maris AB-18-032 AEB45929.1    
 VAB18032_28056   Verrucosispora maris AB-18-032 AEB46684.1    
 VAB18032_28061   Verrucosispora maris AB-18-032 AEB46685.1    
 VAB18032_00775   Verrucosispora maris AB-18-032 AEB47239.1    
 VAB18032_03665   Verrucosispora maris AB-18-032 AEB47815.1    
 VAB18032_03700   Verrucosispora maris AB-18-032 AEB47822.1    
 VAB18032_03705   Verrucosispora maris AB-18-032 AEB47823.1    
 VAB18032_10715   Verrucosispora maris AB-18-032 AEB43261.1    

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