Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | ... | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 VAB18032_10715   Verrucosispora maris AB-18-032 AEB43261.1    
 VAB18032_18340   Verrucosispora maris AB-18-032 AEB44770.1    
 VAB18032_03875   Verrucosispora maris AB-18-032 AEB47857.1    
 VASRM7_27   Verrucosispora sp. MS100047 AIS85266.1    
 VASRM7_633   Verrucosispora sp. MS100047 AIS85875.1    
 VASRM7_23 (probable fragment)   Verrucosispora sp. MS100047 AIS85262.1    
 VASRM7_629 (fragment)   Verrucosispora sp. MS100047 AIS85871.1    
 VASRM7_590   Verrucosispora sp. MS100047 AIS85832.1    
 Vc3S01_A1422   Vibrio campbellii 20130629003S01 ARR09395.1    
 VIBHAR_02510   Vibrio campbellii ATCC BAA-1116 ABU71472.1
AGU95954.1
A7N0D4  
 A8140_08750   Vibrio campbellii CAIM 519 = NBRC 15631 ATCC 25920, CAIM 519T ARV72798.1    
 BA953_01250   Vibrio coralliilyticus 58 ANW22938.1    
 BA953_03735   Vibrio coralliilyticus 58 ANW23390.1    
 JV59_07180   Vibrio coralliilyticus OCN014 AIS54885.1
AIU66849.1
   
 IX92_07115   Vibrio coralliilyticus RE98 AIW18828.1    
 IX92_04635   Vibrio coralliilyticus RE98 AIW18369.1    
 B6A42_08920   Vibrio coralliilyticus SNUTY-1 ARC92201.1    
 B6A42_06085   Vibrio coralliilyticus SNUTY-1 ARC91761.1    
 BSQ33_09945   Vibrio gazogenes ATCC 43942 ASA55983.1    
 BSQ33_21320   Vibrio gazogenes ATCC 43942 ASA58222.1    
 BSQ33_03040   Vibrio gazogenes ATCC 43942 ASA54803.1    
 β-agarase D (AgaD) 3.2.1.81 Vibrio sp. PO-303 BAF34350.1 Q05KJ8  
 CCZ37_17780   Vibrio sp. Q67 ASU24297.1    
 β-agarase (AgaV) 3.2.1.81 Vibrio sp. V134 ABL06969.1 A1E2B6  
 VthA   Vibrio tubiashii RE22 ACD87448.1 B3GCJ8  
 VthA   Vibrio tubiashii X00-12-1(RE98) ACM44932.1 B9VQX8  
 cytolysin (partial)   Vibrio vulnificus ACI29376.1 B6EBE1  
 cytotoxin, partial (VvhA) (fragment)   Vibrio vulnificus 628-7 AEI83799.1    
 VV93_v1c39010   Vibrio vulnificus 93U204 AIL72957.1    
 cytotoxin, partial (VvhA) (fragment)   Vibrio vulnificus ATCC 27562 AEI83835.1    
 AL549_05135   Vibrio vulnificus ATL 6-1306 AMG10720.1    
 hemolysin/cytolysin (VvhA)   Vibrio vulnificus CDC B3547 BAC99984.1 Q75VL6  
 VVCECT4999_19815   Vibrio vulnificus CECT 4999 ASJ40904.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus CIP 75.4T ATCC 27562 AAM97564.1 Q8KHM8  
 hemolysin/cytolysin β-trefoil lectin (VV20404)   Vibrio vulnificus CMCP6 AAO07360.2
AAO07360.1
NP_762370.1
P19247 4OWJ[A,B,C,D,E,F,G]
4OWK[A,B,C,D,E,F,G]
4OWL[A,B,C,D,E,F,G]
 cytolysin (VvhA) (fragment)   Vibrio vulnificus CNRVC 970121 AAM97566.1 Q8KHM8  
 hemolysin/cytolysin A (VvhA)   Vibrio vulnificus FJ03-X2 AGL46605.1    
 FORC9_3806   Vibrio vulnificus FORC_009 ALM73323.1    
 FORC16_3801   Vibrio vulnificus FORC_016 ANH65684.1    
 FORC17_3853   Vibrio vulnificus FORC_017 ANN28916.1    
 FORC36_3773   Vibrio vulnificus FORC_036 ARN68290.1    
 FORC37_3714   Vibrio vulnificus FORC_037 ASC59408.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV10 IFREMER AAM97569.1 Q8KX67  
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV11 IFREMER AAM97570.1 Q8KX66  
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV18 IFREMER AAM97567.1 Q8KX69  
 cytolysin (VvhA) (fragment)   Vibrio vulnificus IF VV24 IFREMER AAM97568.1 Q8KX68  
 hemolysin/cytolysin (VvhA)   Vibrio vulnificus L-180 BAC99982.1 Q75VL8  
 cytolysin, partial (VvhA)   Vibrio vulnificus MO6 AMH86056.1    
 VVM_01835   Vibrio vulnificus MO6-24/O ADV88903.1    
 AOT11_04970   Vibrio vulnificus NBRC 15645 = ATCC 27562 ASM98807.1    
 cytolysin (VvhA) (fragment)   Vibrio vulnificus VV1 AGS13677.1    
 VVA0965   Vibrio vulnificus YJ016 BAC96991.1
NP_937021.1
Q7MDS1  
 AXE80_09265   Wenyingzhuangia fucanilytica CZ1127 ANW96457.1    
 Xaut_1731   Xanthobacter autotrophicus Py2 ABS66976.1 A7IG33  
 XPE_18725   Xanthomonas perforans 91-118 AQS78023.1    
 XPE_18725   Xanthomonas perforans 91-118 AQS78023.1    
 BJD13_23105   Xanthomonas perforans LH3 APP01622.1    
 BJD13_23105   Xanthomonas perforans LH3 APP01622.1    
 SB85_08055   Xanthomonas sacchari R1 AJC45729.1    
 SB85_08055   Xanthomonas sacchari R1 AJC45729.1    
 BN444_02775   Xanthomonas translucens pv. translucens DSM 18974 SCB05689.1    
 BN444_02775   Xanthomonas translucens pv. translucens DSM 18974 SCB05689.1    
 FD63_05115   Xanthomonas translucens pv. undulosa Xtu 4699 AKK66903.1    
 FD63_05115   Xanthomonas translucens pv. undulosa Xtu 4699 AKK66903.1    
 CH48_4014   Yersinia enterocolitica 2516-87 AJJ26016.1    
 YE105_C2363   Yersinia enterocolitica subsp. palearctica 105.5R(r) ADZ42859.1    
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