Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
Protein Name EC#OrganismGenBank UniprotPDB/3D
 NMY3_00190 (AbfB)   Candidatus Nitrocosmicus oleophilus MY3 ALI34404.1    
 rrnAC0205 (AglA2)   Haloarcula marismortui ATCC 43049 AAV45265.1 Q5V5D6  
 rrnB0107   Haloarcula marismortui ATCC 43049 AAV48309.1 Q5UWP4  
 ABY42_16820   Haloferax gibbonsii ARA6 AKU09507.1    
 ABY42_16830   Haloferax gibbonsii ARA6 AKU09509.1    
 Halxa_3778   Halopiger xanaduensis SH-6 AEH38384.1    
 HTIA_1702   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33828.1    
 Huta_2449   Halorhabdus utahensis DSM 12940 ACV12615.1 C7NMH6  
 Huta_2450   Halorhabdus utahensis DSM 12940 ACV12616.1 C7NMH7  
 Huta_1962   Halorhabdus utahensis DSM 12940 ACV12130.1 C7NT55  
 HALLA_02845   Halostagnicola larsenii XH-48 AHG01337.1    
 Htur_4496   Haloterrigena turkmenica DSM 5511 ADB63307.1 D2S1R0  
 Htur_4504   Haloterrigena turkmenica DSM 5511 ADB63315.1 D2S1R8  
 Htur_3906   Haloterrigena turkmenica DSM 5511 ADB62763.1 D2S066  
 Htur_4084   Haloterrigena turkmenica DSM 5511 ADB62918.1 D2S0M1  
 Htur_4440   Haloterrigena turkmenica DSM 5511 ADB63251.1 D2S1K4  
 Metev_1289   Methanohalobium evestigatum Z-7303 ADI74152.1 D7E7S9  
 Mpsy_3151   Methanolobus psychrophilus R15 AFV25350.1    

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