Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T9 2.4.1.41 Rattus norvegicus AAK54498.1
EDM04502.1
NP_570098.1
Q925R7  
 agglutinin (RSA) (partial)   Rhizoctonia solani 207.84 (AG-1C)     4G9M[A]
4G9N[A,B]
4G9M[B]
 agglutinin (RSA)   Rhizoctonia solani AG-3 AGL80208.1    
 ricin B-chain (RTB)   Ricinus communis AAY06525.1
AAB22582.1
ABC05333.1
ACY38598.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
AFH96941.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
D0VFC4
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 ricin B-chain (RTB)   Ricinus communis AAY06525.1
AAB22582.1
ABC05334.1
ACY38598.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
AFH96941.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
D0VFC4
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 ORF   Saccoglossus kowalevskii AOR07040.1    
 Sakowv30026278mg   Saccoglossus kowalevskii APU50785.1    
 BT072538 (fragment)   Salmo salar ACN60295.1 C0PUL4  
 sialic acid-binding dwarf elder agglutinin / rRNA N-glycosylase (SEA;AR) (partial)   Sambucus ebulus CAQ42478.1 B5WYH8  
 sialic acid-binding dwarf elder agglutinin / rRNA N-glycosylase (SEA;AR) (partial)   Sambucus ebulus CAQ42478.1 B5WYH8  
 dimeric lectin SELld / SEL blo   Sambucus ebulus AAM94880.1 Q7XJA6  
 dimeric lectin SELld / SEL blo   Sambucus ebulus AAM94880.1 Q7XJA6  
 lectin (Llm1)   Sambucus ebulus CAM33270.1 A7WM72  
 lectin (Llm1)   Sambucus ebulus CAM33270.1 A7WM72  
 ebulin 1 / ebulin blo / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus CAC33178.1
AAB27855.1
ABC05335.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ebulin 1 / ebulin blo / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus CAC33178.1
ABC05336.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 lectin (AIVl4)   Sambucus nigra AAL04122.1 Q945S3  
 lectin (AIVl4)   Sambucus nigra AAL04122.1 Q945S3  
 lectin (AIVl3)   Sambucus nigra AAL04121.1 Q93WL1  
 lectin (AIVl3)   Sambucus nigra AAL04121.1 Q93WL1  
 lectin (AIVl2)   Sambucus nigra AAL04120.1 Q93WL1  
 lectin (AIVl2)   Sambucus nigra AAL04120.1 Q93WL1  
 lectin (AIVl1)   Sambucus nigra AAL04119.1 Q945S4  
 lectin (AIVl1)   Sambucus nigra AAL04119.1 Q945S4  
 type 2 ribosome-inactivating protein SNAIf precursor (Lecsnα-iF)   Sambucus nigra AAC49989.1    
 type 2 ribosome-inactivating protein SNAIf precursor (Lecsnα-iF)   Sambucus nigra AAC49989.1    
 ribosome inactivating protein precursor   Sambucus nigra AAC15886.1    
 ribosome inactivating protein precursor   Sambucus nigra AAC15886.1    
 lectin precursor   Sambucus nigra AAC15885.1    
 lectin precursor   Sambucus nigra AAC15885.1    
 dimeric lectin (SNAld)   Sambucus nigra AAN86131.1 Q8GTA6  
 dimeric lectin (SNAld)   Sambucus nigra AAN86131.1 Q8GTA6  
 SSA-B-3A (LecSSA-B-3A)   Sambucus racemosa subsp. sieboldiana BAD93340.1 Q58A89  
 SSA-B-3A (LecSSA-B-3A)   Sambucus racemosa subsp. sieboldiana BAD93340.1 Q58A89  
 SSA-B-3B (LecSSA-B-3B)   Sambucus racemosa subsp. sieboldiana BAD93341.1 Q58A88  
 SSA-B-3B (LecSSA-B-3B)   Sambucus racemosa subsp. sieboldiana BAD93341.1 Q58A88  
 SSA-B-3C (LecSSA-B-3C)   Sambucus racemosa subsp. sieboldiana BAD93342.1 Q58A87  
 SSA-B-3C (LecSSA-B-3C)   Sambucus racemosa subsp. sieboldiana BAD93342.1 Q58A87  
 SSA-B-4 (LecSSA-B-4)   Sambucus racemosa subsp. sieboldiana BAD93343.1 Q58A86  
 SSA-B-4 (LecSSA-B-4)   Sambucus racemosa subsp. sieboldiana BAD93343.1 Q58A86  
 polypeptide GalNAc transferase 6 (Pgant6)   Schistosoma japonicum CAX73827.1    
 polypeptide GalNAc transferase 6 (Pgant6)   Schistosoma japonicum CAX73828.1    
 ORF   Schistosoma japonicum AAW26230.1 Q5DD76  
 SJCHGC04837 (fragment)   Schistosoma japonicum AAX27174.2 Q5BZK1  
 Smp_159490   Schistosoma mansoni Puerto Rico CAZ34341.1
CCD81426.1
C4QFV6  
 sscle_02g015110   Sclerotinia sclerotiorum 1980 UF-70 APA06741.1    
 PIIN_01243   Serendipita indica DSM 11827 CCA67412.1    
 PIIN_04393   Serendipita indica DSM 11827 CCA70455.1    
 PIIN_08292   Serendipita indica DSM 11827 CCA74339.1    
 PIIN_01237   Serendipita indica DSM 11827 CCA67406.1    
 PIIN_09434   Serendipita indica DSM 11827 CCA75451.1    
 N-acetylgalactosaminyltransferase (fragment)   Simulium nigrimanum ACZ28391.1 D1FQD6  
 SRAE_1000283400   Strongyloides ratti ED321 Heterogonic CEF64581.1    
 SRAE_2000050400 (fragment)   Strongyloides ratti ED321 Heterogonic CEF65829.1    
 SRAE_X000124600   Strongyloides ratti ED321 Heterogonic CEF59498.1    
 SRAE_2000348700   Strongyloides ratti ED321 Heterogonic CEF68832.1    
 SRAE_2000233200   Strongyloides ratti ED321 Heterogonic CEF67671.1    
 SRAE_2000174000   Strongyloides ratti ED321 Heterogonic CEF67075.1    
 SRAE_2000031600   Strongyloides ratti ED321 Heterogonic CEF65639.1    
 SRAE_0000017900   Strongyloides ratti ED321 Heterogonic CEF61049.1    
 polypeptide N-acetylgalactosaminyltransferase T1 2.4.1.41 Sus scrofa BAA12800.1 Q29121  
 clotting factor G α-subunit   Tachypleus tridentatus BAA04044.1
ACC16493.1
CAL49866.1
Q27082  
 R-type lectin   Tenebrio molitor CCV65019.1    
 MYCTH_89958   Thermothelomyces thermophila ATCC 42464 AEO61028.1    
 THITE_118864   Thielavia terrestris NRRL 8126 XP_003652847.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55423.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55485.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55485.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55518.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55519.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55540.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55540.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55545.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55545.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55595.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55598.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55598.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55614.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55619.1    
 secreted protein   Thraustotheca clavata ATCC 34112 AIG55751.1    
 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T3 (ppGalNAc-T3) 2.4.1.41 Toxoplasma gondii AAQ95173.1
AAO20278.1
Q6YBY0  
 RBL (TvRBL)   Trichoderma viride AIZ77171.1    
 lectin (SGSL)   Trichosanthes anguina     4HR6[C]
 lectin (SGSL)   Trichosanthes anguina     4HR6[C]
 ORF   Trichosporon asahii TIMM 1318 BAB20765.1 Q9HFB0  
 VIGAN_01092100 (Vigan.01g092100)   Vigna angularis var. angularis BAT73439.1    
 ribosome-inactivating protein   Viscum album AAT37532.1 Q6ITZ3 1PC8[B]
1TFM[B]
1YF8[B]
 ribosome-inactivating protein   Viscum album AAT37532.1 Q6ITZ3 1PC8[B]
1TFM[B]
1YF8[B]
 lectin I (ML-I)   Viscum album AAR25545.1
AAL87006.1
AAR25546.1
ABA32657.1
ABA32659.1
ABA32660.1
ABA32661.1
ABA32662.1
ABA32663.1
ABA32664.1
P81446
P81830
1ONK[B]
1OQL[B]
1SZ6[B]
2R9K[B]
2RG9[B]
3CEF[B]
3D7W[B]
3O5W[B]
4EB2[B]
4JKX[B]
 lectin I (ML-I)   Viscum album AAR25545.1
AAL87006.1
AAR25546.1
ABA32657.1
ABA32659.1
ABA32660.1
ABA32661.1
ABA32662.1
ABA32663.1
ABA32664.1
P81446
P81830
1ONK[B]
1OQL[B]
1SZ6[B]
2R9K[B]
2RG9[B]
3CEF[B]
3D7W[B]
3O5W[B]
4EB2[B]
4JKX[B]
 lectin   Viscum album AAR25549.1 Q6H266  
 lectin   Viscum album AAR25549.1 Q6H266  
 lectin   Viscum album AAR25548.1 P82683  
 lectin   Viscum album AAR25548.1 P82683  
 lectin   Viscum album AAR25551.1 Q6H266  
 lectin   Viscum album AAR25551.1 Q6H266  
 lectin   Viscum album AAR25550.1 Q6H266  
 lectin   Viscum album AAR25550.1 Q6H266  
 lectin   Viscum album AAR25547.1 P82683  
 lectin   Viscum album AAR25547.1 P82683  
 Sequence 1 from patent US 6927207   Viscum album ABA32654.1
ABA32656.1
ABA32668.1
   
 Sequence 1 from patent US 6927207   Viscum album ABA32654.1
ABA32656.1
ABA32668.1
   
 lectin B-chain   Viscum album CAB69394.1
CAB69397.1
   
 lectin B-chain   Viscum album CAB69394.1
CAB69397.1
   
 articulatin   Viscum articulatum ABU95610.1 B3F5I6  
 articulatin   Viscum articulatum ABU95610.1 B3F5I6  
 agglutinin (VCA)   Viscum coloratum AAL40417.1 Q8W243  
 agglutinin (VCA)   Viscum coloratum AAL40417.1 Q8W243  
 Sequence 10 from patent US 6846913   Viscum coloratum AAX04115.1 Q8LKQ2  
 Sequence 10 from patent US 6846913   Viscum coloratum AAX04115.1 Q8LKQ2  
 lectin   Viscum coloratum AAY34343.1 Q4U4N0  
 lectin   Viscum coloratum AAY34343.1 Q4U4N0  
 ribosome-inactivating protein precursor, partial   Viscum ovalifolium AEL79474.1    
 ribosome-inactivating protein precursor, partial   Viscum ovalifolium AEL79474.1    
 Ricin B lectin domain   Xanthophyllomyces dendrorhous CED83142.1    
 Ricin B lectin domain   Xanthophyllomyces dendrorhous CED83142.1    
 MGC68664 (xGalNT-1)   Xenopus laevis AAH60419.1 Q6PA81  
 MGC78803 (xGalNT-7)   Xenopus laevis AAH70527.1 Q6NS24  
 MGC81150 (xGalNT-4)   Xenopus laevis AAH71009.1 Q6IR91  
 MGC83963   Xenopus laevis AAH74234.1 Q6GM51  
 MGC81846 (xGalNT-11)   Xenopus laevis AAH80006.1 Q68F39  
 MGC130697 (xGalNT-6)   Xenopus laevis AAI10707.1 Q2TAV9  
 MGC154539   Xenopus laevis AAI24896.1 Q08B33  
 MGC160938 (xGalntl-1)   Xenopus laevis AAI42582.1 A5PKR1  
 MGC:76103   Xenopus tropicalis AAH67317.1 Q6NX21  
 Unknown (protein for MGC:79650)   Xenopus tropicalis AAH75106.1 Q6DJR8  
 TGas006c10.1-001   Xenopus tropicalis CAJ81616.1 Q28D20  
 TGas071o13.1-001   Xenopus tropicalis CAJ83416.1
AAI21348.1
AAI35810.1
Q28CC6  
 Unknown (protein for MGC:146638)   Xenopus tropicalis AAI21473.1 Q0V9M3  
 Unknown (protein for MGC:145354)   Xenopus tropicalis AAI21876.1 Q0P4W5  
 Unknown (protein for MGC:147591)   Xenopus tropicalis AAI21701.1 Q0IIR5  
 Unknown (protein for MGC:147602)   Xenopus tropicalis AAI24052.1
AAI35912.1
Q08CX0  
 Unknown (protein for IMAGE:7719810)   Xenopus tropicalis AAI25762.1 A0JM69  
 riproximin (rpx)   Ximenia americana CAJ38823.1 Q2PA54  
 riproximin (rpx)   Ximenia americana CAJ38823.1 Q2PA54  
 unknown (ZM_BFc0001H02)   Zea mays B73 ACF84223.1 B4FQ30  
 unknown (ZM_BFc0001H02)   Zea mays B73 ACF84223.1 B4FQ30  
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF   uncultured organism AAN27792.1
AAP87538.1
Q7TLZ3  
 ORF (fragment)   uncultured organism AGU11696.1    
 ORF, partial   uncultured organism AGU11902.1    
 ORF, partial   uncultured organism AGU11902.1    
 Sequence 8 from patent US 7485308   unidentified ACN05175.1    
 Sequence 12 from patent US 6846913   unidentified AAX04116.1    
 Sequence 12 from patent US 6846913   unidentified AAX04116.1    
 Sequence 5 from patent US 6939698 (fragment)   unidentified ABA38427.1    
 Sequence 6 from patent US 6939698 (fragment)   unidentified ABA38428.1    
 Sequence 274 from patent US 7247715   unidentified ABU38998.1    
 Sequence 274 from patent US 7247715   unidentified ABU38998.1    
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 MAMA_L361   Acanthamoeba castellanii mamavirus Hal-V AEQ60476.1    
 ORF   Acanthamoeba castellanii mimivirus Mimivirus kasaii BAV61387.1    
 ORF   Acanthamoeba castellanii mimivirus Mimivirus shirakomae BAV62375.1    
 MIMI_L288   Acanthamoeba polyphaga mimivirus AAV50560.1
ADO18119.1
AEJ34527.1
E3VZN6
Q5UPX2
 
 ORF   Acanthamoeba polyphaga mimivirus Amazonia AKI80952.1    
 ORF   Acanthamoeba polyphaga mimivirus Kroon AKI80023.1    
 ORF   Acanthamoeba polyphaga mimivirus Oyster AKI79058.1    
 Catovirus_2_39   Catovirus CTV1 ARF09090.1    
 Catovirus_1_251   Catovirus CTV1 ARF08201.1    
 toxin (Ha1)   Clostridium botulinum D phage CB16 BAA75077.1   1QXM[A,B]
2EHI[A,B]
2EHM[A,B]
2EHN[A,B]
 toxin (Ha1)   Clostridium botulinum D phage CB16 BAA75077.1   1QXM[A,B]
2EHI[A,B]
2EHM[A,B]
2EHN[A,B]
 toxin (Ha1;Hα-33;Antp-33)   Clostridium botulinum phage 1C 468 CAA51311.1 P46084
Q38196
3AH1[A,B]
3AH2[A,B]
3AH4[A,B]
 toxin (Ha1;Hα-33;Antp-33)   Clostridium botulinum phage 1C 468 CAA51311.1 P46084
Q38196
3AH1[A,B]
3AH2[A,B]
3AH4[A,B]
 CST084   Clostridium phage c-st BAE47782.1 Q332E2  
 CST084   Clostridium phage c-st BAE47782.1 Q332E2  
 HIRU_S671   Hirudovirus strain Sangsue AHA45577.1    
 ORF   Mimivirus Bombay AMZ02737.1    
 ORF   Niemeyer virus ALR83869.1    
 HARRISON_30   Paenibacillus phage Harrison ALA12432.1    
 HARRISON_30   Paenibacillus phage Harrison ALA12432.1    
 PAISLEY_30   Paenibacillus phage Paisley ALA12593.1    
 PAISLEY_30   Paenibacillus phage Paisley ALA12593.1    
 IBBP123_26   Paenibacillus phage phiIBB_Pl23 AGN89341.1    
 IBBP123_26   Paenibacillus phage phiIBB_Pl23 AGN89341.1    
 β-type lectin protein   Samba virus AHJ40019.2    
 L279   Samba virus AHJ40019.1    
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