Auxiliary Activity Family 9

Activities in FamilyAA9 (formerly GH61) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of cellulose chains with oxidation of various carbons (C-1, C-4 and C-6) has been reported several times in the literature;
Mechanism monooxygenase
NoteAA9 (formerly GH61). The enzymes in this family were originally classified as a glycoside hydrolases (GH61) based on very weak endo-1,4-b-D-glucanase activity in one family member. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name GH61, we recommend to describe these enzymes as "AA9 (formerly GH61)".
External resourcesCAZypedia;
Statistics GenBank accession (432); Uniprot accession (135); PDB accession (26); 3D entries (12); cryst (0)
All (352) Eukaryota (352) Structure (12) Characterized (26)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lytic polysaccharide monooxygenase (active on cellooligosaccharides) / auxiliary activity 9 (LsAA9A) 1.-.-.- Lentinus similis ALN96977.1  
5ACF[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.80
5ACG[A] 1.91
5ACH[A] 1.28
5ACI[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.75
5ACJ[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.70
5N04[A] 1.76
5N05[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
1.58
 lytic polysaccharide monooxygenase (active on cellulose) (PMO-2;NcPMO-2;NcLPMO9D;GH61-4;NCU01050) (LPMO9D) 1.-.-.- Neurospora crassa OR74A CAD21296.1
EAA32426.1
XP_326543.1
Q1K8B6
Q8WZQ2
4EIR[A,B] 1.10
5TKF[A,B,C,D] 2.10
5TKG[A,B] 1.20
5TKH[A,B] 1.20
5TKI[A,B] 1.50
 lytic polysaccharide monooxygenase 9F (active on cellulose) (PMO-03328;LPMO-03328;NcLPMO9F;GH61-6;NCU03328) (LPMO9F) 1.-.-.- Neurospora crassa OR74A CAD70347.1
EAA26656.1
XP_322586.1
Q1K4Q1
Q873G1
4QI8[A,B] 1.10
 lytic polysaccharide monooxygenase (active on cellulose) (PMO-3;NcLPMO9M;GH61-13;NcPMO-3;NCU07898) (LPMO9M) 1.-.-.- Neurospora crassa OR74A EAA33178.1
XP_328604.1
Q7SA19
4EIS[A,B] 1.37
 lytic polysaccharide monooxygenase (active on cellulose and cellooligosaccharides) (PMO-02916;LPMO-02916;NcLPMO9C;GH61-3;NCU02916) (LPMO9C) 1.-.-.- Neurospora crassa OR74A EAA36362.1
XP_330104.1
Q7SHI8
4D7U[A,B] 1.56
4D7V[A,B] 1.90
 lytic polysaccharide monooxygenase (active on cellulose) (GH61-1;NcLPMO9A;NCU02240) 1.-.-.- Neurospora crassa OR74A EAA30263.1
XP_331016.1
Q7S439
5FOH[A] 1.60
 Lytic polysaccharide mono-oxygenase active on cellulose (Gh61D;PcGH61D;PcLPMO9D) 1.-.-.- Phanerochaete chrysosporium K-3 BAL43430.1  
4B5Q[A,B] 1.75
 lytic polysaccharide mono-oxygenase active on cellulose (TaAA9;TaAA9A;TaGH61;TaGH61A;TaLPMO9A) 1.-.-.- Thermoascus aurantiacus ACS05720.1
ABW56451.1
 
2YET[A,B] 1.50
3ZUD[A] 1.25
 lytic polysaccharide monooxygenases (active on cellulose) (MtPMO3;MYCTH_92668) 1.-.-.- Thermothelomyces thermophila ATCC 42464 AEO56665.1  
5UFV[A,B,C,D,E,F] 2.45
 THITE_2122979   Thielavia terrestris NRRL 8126 XP_003657366.1
ACE10234.1
AEO71030.1
 
3EII[A,B,C,D] 2.25
3EJA[A,B,C,D] 1.90
 lytic polysaccharide mono-oxygenase active on cellulose (EG7;HjGH61B) (Cel61B=GH61B)   Trichoderma reesei QM6A AAP57753.1
ABH82048.1
ACK19226.1
ACR92640.1
Q7Z9M7
2VTC[A,B] 1.6
 lytic cellulose monooxygenase (EGIV;Egl4;EG4) (formerly endo-β-1,4-glucanase IV) (LPMO9A) 1.-.-.- Trichoderma reesei RUTC-30 CAA71999.1 O14405
5O2W[A]
5O2X[A]
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