Auxiliary Activity Family 3

Activities in Familycellobiose dehydrogenase (EC 1.1.99.18); glucose 1-oxidase (EC 1.1.3.4); aryl alcohol oxidase (EC 1.1.3.7); alcohol oxidase (EC 1.1.3.13); pyranose oxidase (EC 1.1.3.10); glucose 1-dehydrogenase (FAD, quinone) (EC 1.1.5.9); pyranose dehydrogenase (EC 1.1.99.29); oligosaccharide dehydrogenase (FAD) (EC 1.1.5.-)
NoteAA3 enzymes belong to the glucose-methanol-choline (GMC) oxidoreductases family. AA3 enzymes are flavoproteins containing a flavin-adenine dinucleotide (FAD)-binding domain. Family AA3 can be divided into 4 subfamilies: AA3_1 (mostly cellobiose dehydrogenases), AA3_2 (including both aryl alcohol oxidase and glucose 1-oxidase), AA3_3 (alcohol oxidase) and AA3_4 (pyranose 2-oxidase).
External resourcesCAZypedia;
Statistics GenBank accession (2567); Uniprot accession (44); PDB accession (54); 3D entries (18); cryst (1)
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 pyranose dehydrogenase (PDH;AcPDH) 1.1.99.29   Agaricus campestris AHA85313.1 V5NDL4   2
 pyranose dehydrogenase (PDH;AxPDH) 1.1.99.29   Agaricus xanthodermus AHA85314.1 V5NC32   2
 glucose dehydrogenase (GDH,G4B84_001660) 1.1.5.9 pubmed
Aspergillus flavus NRRL3357 QMW26415.1   4YNT[A]
4YNU[A]
2
 glucose oxidase (GgoX) 1.1.3.4   Aspergillus niger CAC12802.1 Q9HFQ1   2
 glucose oxidase (Gox1) 1.1.3.4   Aspergillus niger AAA32695.1
AAB12628.1
AAQ78793.1
ACB30369.1
CAA34197.1
CAC27315.1
CAC83816.1
B2CNX8
P13006
1CF3[A]
1GAL[A]
3QVP[A]
3QVR[A]
5NIT[A]
5NIW[A]
2
 alcohol oxidase (AOx) 1.1.3.13   Aspergillus terreus MTCC 6324 AFP17823.1 I7FDJ2   3
 alcohol oxidase (P68;Hv-p68) 1.1.3.13   Bipolaris victoriae ATTC 42018 AAK14990.1 Q9C1S3   3
 ecdysone oxidase (BmEO;BGIBMGA005692) 1.1.3.16   Bombyx mori AEM17059.1 H6AGY0   2
 methanol oxidase (Aod1;AOD1) 1.1.3.13   Candida boidinii S2 / AOU-1 AAA34321.1 Q00922   3
 cellobiose dehydrogenase (CdhIIA) 1.1.99.18   Chaetomium atrobrunneum CBS 238.71 ADT70773.1 E7D6C0   1
 cellobiose dehydrogenase IIA (Cdh;MtCDH) 1.1.99.18   Crassicarpon hotsonii ABS45567.2
ABS45566.1
A9XK87
A9XK88
4QI4[A]
4QI5[A]
4QI6[A]
1
 cellobiose dehydrogenase (CdhIIB) 1.1.99.18   Crassicarpon thermophilum CBS 405.69 ADT70772.1 E7D6B9   1
 cellobiose dehydrogenase (CdhIIA) 1.1.99.18   Dichomera saubinetii CBS 990.70 ADT70774.1 E7D6C1   1
 cellobiose dehydrogenase (Cdh) 1.1.99.18   Gelatoporia subvermispora FP-90031 ACF60617.1 B6D1P2   1
 alcohol oxidase (AoX) 1.1.3.13   Gloeophyllum trabeum ATCC 11539 / M617 ABI14440.1 A8DPS4   3
 cellobiose dehydrogenase (CdhIIB) 1.1.99.18   Hypoxylon haematostroma CBS 255.63 ADT70776.1 E7D6C3   1
 alcohol oxidase / methanol oxidase (Aox1;AOX1;MOX1) 1.1.3.13   Komagataella pastoris NRRL Y-11430 AAB57849.1 F2QY27
P04842
5HSA[A,B,C,D,E,F,G,H]
5I68[A]
3
 alcohol oxidase (Aox2;AOX2) 1.1.3.13   Komagataella pastoris NRRL Y-11430 AAB57850.1 F2R038
P04842
  3
 pyranose dehydrogenase (Pdh1;PDH;AmPDH) 1.1.99.29   Leucoagaricus meleagris AAW82996.1
AAW82997.1
Q3L245 4H7U[A] 2
 pyranose 2-oxidase (P2Ox;LsP2O) 1.1.3.10   Lyophyllum shimeji BAD12079.1
Q75ZP8.1
Q75ZP8   4
 methanol oxidase (MOX;Mp-Mox) 1.1.3.13   Moniliophthora perniciosa AFO55203.1 I7CMK2   3
 cellobiose dehydrogenase IIA (Cdh-1;CDH-1;CdhIIA;Nc-Cdh1;NCU00206) 1.1.99.18   Neurospora crassa OR74A EAA27355.1
XP_322292.1
Q7RXM0 4QI7[A,B] 1
 cellobiose dehydrogenase IIB (Cdh2;CdhIIB;Nc-Cdh2;NCU05923) 1.1.99.18   Neurospora crassa OR74A EAA28998.1 Q7S0Y1   1
 alcohol oxidase / methanol oxidase (Mox1;MOX) 1.1.3.13   Ogataea angusta DL1 CAA26278.1
CAM84030.1
CAM84031.1
CAM84032.1
A6PZG7
A6PZG8
A6PZG9
P04841
  3
 glucose oxidase 1.1.3.4   Penicillium amagasakiense   P81156 1GPE[A,B] 2
 glucose oxidase (GodP;GOD-w) 1.1.3.4   Penicillium chrysogenum F4 AFA42947.1 K9L4P7   2
 pyranose 2-oxidase / glucose 2-oxidase 1.1.3.10   Peniophora sp. SG AAO13382.1 Q8J136 1TZL[A,B,C,D,E,F,G,H]
2F5V[A]
2F6C[A]
4
 pyranose 2-oxidase (PoX) 1.1.3.10   Phanerochaete chrysosporium BKM-F-1767 AAS93628.1
Q6QWR1.1
Q6QWR1 4MIF[A,B,C,D]
4MIG[A,B,C,D]
4MIH[A,B,C,D,E,F,G,H]
4
 alcohol oxidase (Aox1) 1.1.3.13   Phanerochaete chrysosporium DSMZ 1547 CDG66232.1 T2M2J4 6H3G[A,B,C,D,E,F,G,H]
6H3O[A,B,C,D,E,F,G,H]
3
 cellobiose dehydrogenase I (CdH) 1.1.99.18   Phanerochaete chrysosporium K3 CAA61359.1 Q12661   1
 aryl-alcohol oxidase (AaO) 1.1.3.7   Pleurotus eryngii ATCC90787; CBS 613.91; IJFM A169 AAC72747.1 O94219 3FIM[B]
5OC1[A]
2
 aryl-alcohol oxidase (AaO) 1.1.3.7   Pleurotus pulmonarius CBS 507.85 AAF31169.1 Q9P928 cryst 2
 cellobiose dehydrogenase (CdhIIA2) 1.1.99.18   Stachybotrys bisbyi DSM 630.42 ADT70778.1 E7D6C5   1
 cellobiose dehydrogenase (Cdh;MYCTH_111388) 1.1.99.18   Thermothelomyces thermophilus ATCC 42464 AEO58137.1
AAC26221.1
O74240   1
 cellobiose dehydrogenase (CDH-2;MtCDH-2;MYCTH_81925) 1.1.99.18   Thermothelomyces thermophilus ATCC 42464 AEO59298.1 G2QFY4   1
 cellobiose dehydrogenase (CbdA,THITE_59724) 1.1.99.18   Thermothielavioides terrestris NRRL 8126 AEO69014.1 G2RB43   1
 oligosaccharide dehydrogenase (ODH;BN946_scf184803.g17) 1.1.5.- pubmed
Trametes cinnabarina BRFM137 CDO69819.1   6XUT[A]
6XUU[A]
6XUV[A]
2
 cellobiose dehydrogenase 1.1.99.18   Trametes cinnabarina ss3 / BRFM 137 ADX41688.1 F1DFN2   1
 pyranose 2-oxidase (P2O;TmP2O) 1.1.3.10   Trametes ochracea MB49 AAP40332.1 Q7ZA32 4MOE[A,B,C,D]
4MOF[A]
4MOG[A]
4MOH[A]
4MOI[A,B]
4MOJ[A,B,C,D]
4MOK[A,B,C,D]
4MOL[A,B,C,D]
4MOM[A,B,C,D]
4MOO[A]
4MOP[A,B,C,D]
4MOQ[A,B]
4MOR[A,B,C,D]
4MOS[A]
4
 pyranose oxidase (P2O) 1.1.3.10   Trametes pubescens CBS 696.94 AAW57304.1 Q5G234   4
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