Activities in Family	Laccase / p-diphenol:oxygen oxidoreductase / ferroxidase (EC 1.10.3.2); ; ferroxidase (EC 1.10.3.-); Laccase-like multicopper oxidase (EC 1.10.3.-)
Note	The characterized AA1 enzymes are multicopper oxidases that use diphenols and related substances as donors with oxygen as the acceptor. The AA1 family is currently divided into 3 subfamilies including laccases, ferroxidases and laccase-like multicopper oxidases.
Statistics	GenBank accession (6141); Uniprot accession (79); PDB accession (89); 3D entries (25); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
Pdw03_7158		Penicillium digitatum PdW03	QQK43257.1			3
Pdw03_7982		Penicillium digitatum PdW03	QQK44081.1			2
Pdw03_7409		Penicillium digitatum PdW03	QQK43508.1			2
Pdw03_0562		Penicillium digitatum PdW03	QQK45664.1			3
Pc21g08020		Penicillium rubens Wisconsin 54-1255	CAP95699.1			2
Pc22g08410		Penicillium rubens Wisconsin 54-1255	CAP98129.1			3
laccase (fragment)		Peniophora incarnata	AJK28607.1			1
laccase C		Peniophora lycii	AWC08468.1			1
laccase B		Peniophora lycii	AWC08467.1			1
laccase A		Peniophora lycii	AWC08466.1			1
laccase 5, partial		Peniophora lycii	UNO37639.1			1
laccase 4, partial		Peniophora lycii	UNO37638.1			1
laccase (fragment)		Peniophora lycii	AFQ90523.1			1
laccase 3B (LcC)		Peniophora sp. CBMAI 1063	AUK50747.1			1
laccase 5B (LcC)		Peniophora sp. CBMAI 1063	AUK50750.1			1
laccase 3 (LcC)		Peniophora sp. CBMAI 1063	AUK50746.1			1
laccase 1 (LcC)		Peniophora sp. CBMAI 1063	AUK50744.1			1
laccase 7 (LcC)		Peniophora sp. CBMAI 1063	AUK50752.1			1
laccase 5 (LcC)		Peniophora sp. CBMAI 1063	AUK50749.1			1
laccase 2 (LcC)		Peniophora sp. CBMAI 1063	AUK50745.1			1
laccase 8 (LcC)		Peniophora sp. CBMAI 1063	AUK50753.1			1
laccase 6 (LcC)		Peniophora sp. CBMAI 1063	AUK50751.1			1
laccase 4 (LcC)		Peniophora sp. CBMAI 1063	AUK50748.1			1
KXD40_000929 (fragment)		Peronospora effusa	UIZ21019.1
KXD40_002624		Peronospora effusa	UIZ26495.1
KXD40_002623		Peronospora effusa	UIZ26488.1
PtaK		Pestalotiopsis fici CGMCC3.15140	AGO59052.1			3
PtaE		Pestalotiopsis fici CGMCC3.15140	AGO59042.1			3
multicopper oxidase		Pestalotiopsis microspora NK17	QED41496.1			3
laccase 2, partial		Pestalotiopsis sp.	AVO20570.1			3
laccase 1, partial		Pestalotiopsis sp.	AVO20569.1			3
ORF (fragment)		Pezoloma ericae	ANW36309.1
laccase 2 (Lac2)		Phaedon cochleariae	AWK23446.1
laccase (LacD)		Phanerochaete avellanea	ALF95043.1			1
laccase		Phanerochaete avellanea	ALF95042.1			1
laccase (LacB)		Phanerochaete avellanea	ALF95041.1			1
laccase (LacA)		Phanerochaete avellanea	ALF95040.1			1
laccase (LacE)		Phanerochaete avellanea	ALF95044.1			1
laccase (fragment)		Phanerochaete avellanea 2009	AFQ90521.1			1
ORF (fragment)		Phialocephala fortinii	ANW36310.1			2
laccase II (LacII)		Phlebia brevispora BAFC 633	UNY77501.1			1
laccase (LacI)		Phlebia brevispora BAFC 633	AFK30375.1 AFK30375.2			1
laccase G, partial (fragment)		Phlebia chrysocreas	AYR00608.1
laccase F, partial (fragment)		Phlebia chrysocreas	AYR00607.1			1
Lac2 protein (Lac2)		Phlebia radiata	CAI56705.1			1
laccase (LaC)		Phlebia radiata 79	CAA36379.2			1
multicopper oxidase (Lac1)		Phlebia tremellosa	CAK54346.1			1
multiple oxidase (Lac1)		Phlebia tremellosa PT05-2	CAR47803.1			1
laccase (Pnlcc8)		Pholiota microspora NGW19-6	BAU94254.1			1
laccase (Pnlcc4)		Pholiota microspora NGW19-6	BAU94250.1			1
laccase (Pnlcc9)		Pholiota microspora NGW19-6	BAU94255.1			2
laccase (Pnlcc1)		Pholiota microspora NGW19-6	BAU94247.1			1
laccase (Pnlcc2)		Pholiota microspora NGW19-6	BAU94248.1			1
laccase (Pnlcc5)		Pholiota microspora NGW19-6	BAU94251.1			1
laccase (Pnlcc3)		Pholiota microspora NGW19-6	BAU94249.1			1
laccase (Pnlcc6)		Pholiota microspora NGW19-6	BAU94252.1			1
laccase (Pnlcc7)		Pholiota microspora NGW19-6	BAU94253.1			1
laccase (Lac1)		Pholiota nameko Ph-5(3)	ABR24264.1			1
laccase (Lac1)	1.10.3.2	Phoma sp. UHH 5-1-03 (DSM 22425)	ABY89704.1 ABY89705.1	B3TLA6		3
laccase		Phomopsis liquidambaris B3	AGZ62514.1			3
laccase (Lac2)		Phytophthora capsici	AFY09916.1
laccase (Lac1)		Phytophthora capsici	AFY09915.1
laccase (Lac1)		Picea abies	AFV52377.1
laccase (Lac3A)		Picea abies	AFV52379.1
laccase (Lac3B)		Picea abies	AFV52380.1
laccase (Lac3C)		Picea abies	AFV52381.1
laccase (Lac5A)		Picea abies	AFV52383.1
laccase (Lac5B)		Picea abies	AFV52384.1
laccase (Lac4)		Picea abies	AFV52382.1
laccase (Lac2)		Picea abies	AFV52378.1
FET3		Pichia kudriavzevii	AWT08580.1			2
FET3		Pichia kudriavzevii	AWT08579.1			2
C5L36_0A01420		Pichia kudriavzevii CBS573	AWU73536.1			2
C5L36_0B04090		Pichia kudriavzevii CBS573	AWU75157.1			2
ORF (fragment)		Piloderma byssinum	AAM95784.1
ORF (fragment)		Piloderma croceum	AAM95788.1
0_8531_01 (fragment)		Pinus cembra	AFB33035.1 AFB33030.1 AFB33031.1 AFB33032.1 AFB33033.1 AFB33034.1
laccase, partial (fragment)		Pinus mugo	AIW39730.1
laccase, partial (fragment)		Pinus mugo	AIW39731.1
laccase, partial (fragment)		Pinus mugo	AIW39732.1
laccase, partial (fragment)		Pinus mugo	AIW39733.1
laccase, partial (fragment)		Pinus mugo	AIW39734.1
laccase 2 (Lac2) (fragment)		Pinus pinaster	AFL65035.1
laccase 4 (Lac4) (short fragment)		Pinus pinaster	AFL65036.1
laccase, partial (Pr4_19) (fragment)		Pinus sylvestris	AIY54924.1
laccase (Lac8)		Pinus taeda	AHX74225.2
laccase-12 (Lac4)		Pinus taeda	AZA14792.1
Laccase-17 (Lac11)		Pinus taeda	AZA14790.1
Laccase-12 (Lac2)		Pinus taeda	AZA14791.1
laccase, partial (PtalaC) (fragment)		Pinus taeda	BBN20949.1
UMN_2767_01 (short fragment)		Pinus taeda	AEX13437.1
laccase (Lac7)		Pinus taeda	AHX74225.1
laccase (short fragment)		Plasmopara viticola	CCC15138.1
laccase 1 (Lac1)		Pleurotus djamor CB1	AHC32223.1			1
laccase (Ery3)		Pleurotus eryngii	CAO79914.1 AGO64759.1			1
laccase		Pleurotus eryngii	ADD14077.1			1
laccase		Pleurotus eryngii	ACI62809.1 ACI62810.1 CAO79915.1			1
laccase (Pel3)	1.10.3.2	Pleurotus eryngii CBS 613.91	AAV85769.1	Q5MP11		1
laccase (Pel4)		Pleurotus eryngii CBS 613.91	ABB30169.1			1
laccase, partial (fragment)		Pleurotus eryngii U8/11	AMB72865.1			1
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