Activities in Family	Laccase / p-diphenol:oxygen oxidoreductase / ferroxidase (EC 1.10.3.2); ; ferroxidase (EC 1.10.3.-); Laccase-like multicopper oxidase (EC 1.10.3.-)
Note	The characterized AA1 enzymes are multicopper oxidases that use diphenols and related substances as donors with oxygen as the acceptor. The AA1 family is currently divided into 3 subfamilies including laccases, ferroxidases and laccase-like multicopper oxidases.
Statistics	GenBank accession (6141); Uniprot accession (79); PDB accession (89); 3D entries (25); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
Lac4, partial (fragment)		Leptosphaerulina sp. LVN6	AID53024.1			3
Lac3, partial (fragment)		Leptosphaerulina sp. LVN6	AID53023.1			3
laccase (Lcc5)		Leucoagaricus gongylophorus Ae322	AFV15789.1			1
laccase (Lcc1)		Leucoagaricus gongylophorus Ae322	AFV15785.1			1
laccase (Lcc2)		Leucoagaricus gongylophorus Ae322	AFV15786.1			1
laccase (Lcc3)		Leucoagaricus gongylophorus Ae322	AFV15787.1			1
laccase (Lcc6)		Leucoagaricus gongylophorus Ae322	AFV15790.1			1
laccase (Lcc7)		Leucoagaricus gongylophorus Ae322	AFV15791.1			1
laccase (Lcc8)		Leucoagaricus gongylophorus Ae322	AFV15792.1			1
laccase (Lcc9)		Leucoagaricus gongylophorus Ae322	AFV15793.1			2
laccase (Lcc4) (fragment)		Leucoagaricus gongylophorus Ae322	AFV15788.1			1
laccase, partial (Lcc1) (fragment)		Leucocoprinus sp. Cyp.lon.C#012_180507	AFV15795.1			1
laccase (Lcc1)		Leucocoprinus sp. Tra.sp1.C#004_270408	AFV15794.1			1
ls5930a1_00020		Leucosporidium scottii	CRX78957.1			2
ls5930a1_00020		Leucosporidium scottii	CRX78957.1			2
LRAMOSA05050		Lichtheimia ramosa	CDS12866.1			2
LRAMOSA04726		Lichtheimia ramosa	CDS12532.1
LRAMOSA06733		Lichtheimia ramosa	CDS03778.1			2
LRAMOSA08713		Lichtheimia ramosa	CDS06185.1
LRAMOSA02612		Lichtheimia ramosa	CDS09935.1			2
LRAMOSA09079		Lichtheimia ramosa	CDS06551.1
LRAMOSA01210		Lichtheimia ramosa	CDS07261.1
laccase (Lac1)		Lignosus rhinocerotis	AXY79772.1			1
laccase (Lac4)		Lignosus rhinocerotis	AYO51536.1			1
ORF		Linum usitatissimum	AFN53658.1
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50277.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50278.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50279.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50280.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50281.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50282.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50283.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50284.1			2
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50285.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50286.1			2
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50287.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50288.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50289.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50290.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50291.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50292.1			2
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50293.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50294.1			2
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50295.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50296.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50297.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50298.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50299.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50300.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50301.1			2
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50302.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50303.1			3
Laccase (fragment)		Lophodermium sp. ZY-2014	AIJ50304.1			3
laccase		Macrotermes barneyi	AFD33366.1
DNF11_0974 (AaO)		Malassezia restricta CBS 7877	AYO41924.1
DNF11_0773 (Fio1)		Malassezia restricta CBS 7877	AYO41723.1			2
DNF11_0975 (Lcc5) (fragment)		Malassezia restricta CBS 7877	AYO41925.1
MRET_1404		Malassezia restricta KCTC 27527	AXA49143.1
MRET_0002		Malassezia restricta KCTC 27527	AXA48447.1			2
MRET_1403 (fragment)		Malassezia restricta KCTC 27527	AXA49146.1
MSYG_3159 (fragment)		Malassezia sympodialis ATCC 42132	SHO78811.1			2
MSYG_4230		Malassezia sympodialis ATCC 42132	SHO79878.1			2
laccase 1		Manduca sexta	AAN17506.1
laccase (Lcc1)		Marasmius cladophyllus UMAS MS8	AMQ22747.1			1
Mp_8g06360		Marchantia polymorpha subsp. ruderalis Tak-1	BBN18889.1
Mp_3g21420		Marchantia polymorpha subsp. ruderalis Tak-1	BBN06467.1
Mp_5g07740		Marchantia polymorpha subsp. ruderalis Tak-1	BBN10939.1
laccase (Mplac1)		Marchantia polymorpha Takaragaike-1	BAV53362.1 BBN06344.1
laccase (Lac1)	1.10.3.2	Melanocarpus albomyces	CAE00180.1	Q70KY3	1GW0[A,B] 2IH8[A,B] 2IH9[A,B] 2Q9O[A,B] 3DKH[A,B] 3FU7[A,B] 3FU8[A,B] 3FU9[A,B]	3
BN887_01910		Melanopsichium pennsylvanicum 4	CDI56165.1
BN887_00542		Melanopsichium pennsylvanicum 4	CDI56230.1
BN887_03586		Melanopsichium pennsylvanicum 4	CDI56287.1
BN887_02113		Melanopsichium pennsylvanicum 4	CDI51050.1			2
BN887_03144 (fragment)		Melanopsichium pennsylvanicum 4	CDI56015.1
ORF (fragment)		Meliniomyces variabilis	ANW36311.1
ORF (fragment)		Meliniomyces variabilis	ANW36313.1
ORF (fragment)		Meliniomyces vraolstadiae	ANW36312.1
laccase (Lac1)		Meripilus giganteus	CBV46340.1			1
G6M90_00g024850 (AsO)		Metarhizium brunneum 4556	QLI63445.1
G6M90_00g000560 (Lcc1)		Metarhizium brunneum 4556	QLI63946.1
G6M90_00g048990 (FetC)		Metarhizium brunneum 4556	QLI66871.1			2
G6M90_00g045570 (Lac1)		Metarhizium brunneum 4556	QLI67119.1			3
G6M90_00g093480 (Abr2_1)		Metarhizium brunneum 4556	QLI72976.1
G6M90_00g113450 (Aurl2_1)		Metarhizium brunneum 4556	QLI74016.1
G6M90_00g102750 (Ptak_2)		Metarhizium brunneum 4556	QLI73216.1
G6M90_00g113980 (Lcc2_2)		Metarhizium brunneum 4556	QLI74493.1			3
G6M90_00g066690 (Lcc2_1)		Metarhizium brunneum 4556	QLI69373.1			3
G6M90_00g079010 (Ptak_1)		Metarhizium brunneum 4556	QLI70642.1			3
G6M90_00g000510 (Lcc2_0)		Metarhizium brunneum 4556	QLI65061.1			3
G6M90_00g080720 (Abr2_0)		Metarhizium brunneum 4556	QLI71336.1
G6M90_00g001230 (Ptak_0)		Metarhizium brunneum 4556	QLI66315.1			3
G6M90_00g052500 (GedJ)		Metarhizium brunneum 4556	QLI68968.1			3
G6M90_00g113820 (Mlac1_1)		Metarhizium brunneum 4556	QLI74771.1
G6M90_00g084150 (AaO)		Metarhizium brunneum 4556	QLI71515.1
G6M90_00g033460 (Aurl2_0)		Metarhizium brunneum 4556	QLI66568.1
G6M90_00g031400 (Mlac1_0)		Metarhizium brunneum 4556	QLI67126.1
METSCH_E02170 (Mpul0e02170)		Metschnikowia aff. pulcherrima APC 1.2	QBM89980.1
METSCH_D08140 (Mpul0d08140)		Metschnikowia aff. pulcherrima APC 1.2	QBM89732.1			2
ORF		Microthielavia ovispora VKM F-1735	QYY49099.1
GNLVRS01_PISO0M17326g (Piso0_005559)		Millerozyma farinosa CBS 7064	CCE85919.1			2
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