Auxiliary Activity Family 13

Activities in FamilyAA13 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of starch with oxidation of C-1 at the site of cleavage has been demonstrated for the LPMO encoded by gene NCU08746 from Neurospora crassa; lytic starch monooxygenase / starch oxidase (glycosidic bond-cleaving) (EC 1.14.99.55)
Mechanism monooxygenase
NoteFamily built after Vu et al. Proc. Natl. Acad. Sci. USA (2014) 111:13822-7 (PMID 25201969);
External resourcesCAZypedia;
Statistics GenBank accession (43); Uniprot accession (7); PDB accession (8); 3D entries (1); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 lytic monooxygenase (AoAA13;AO090701000246;AOR_1_454114) 1.14.99.55 Aspergillus oryzae RIB40 XP_001823115.2
BAE61982.1
Q2U8Y3
4OPB[A] 1.50
5LSV[A] α-D-Glcp-(1-4)-α-D-Glcp
1.10
5T7J[A] 1.65
5T7K[A] 1.30
5T7N[A] α-D-Glcp-(1-6)-α-D-Glcp-(1-4)-α-D-Glcp-(1-4)-α-D-Glcp
1.60
6TBQ[A] 1.72
6TBR[A,B] 1.70
6TC4[A] 2.00
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