Auxiliary Activity Family 10

Activities in FamilyAA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose; lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54); lytic cellulose monooxygenase (C4-dehydrogenating)(EC 1.14.99.56); lytic chitin monooxygenase (EC 1.14.99.53)
Mechanism monooxygenase
NoteAA10 (formerly CBM33). The enzymes in this family were originally classified as chitin-binding proteins (CBM33); Vaaje-Kolstad et al. have shown that these proteins are in fact oxidative enzymes [PMID - 20929773]. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name CBM33, we recommend to describe these enzymes as "AA10 (formerly CBM33)".
Statistics GenBank accession (5205); Uniprot accession (382); PDB accession (36); 3D entries (20); cryst (0)
All (5057) Archaea (3) Bacteria (4872) Eukaryota (9) Viruses (171) unclassified (2) Structure (20) Characterized (23)
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 fusolin; spindle body protein (Gp37)   synthetic baculovirus AcMNPV-WIV-Syn1 ARJ58749.1    
 ORF   uncultured organism AGU11296.1    
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