Auxiliary Activity Family 10

Activities in FamilyAA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose; lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54); lytic cellulose monooxygenase (C4-dehydrogenating)(EC 1.14.99.56); lytic chitin monooxygenase (EC 1.14.99.53)
Mechanism monooxygenase
NoteAA10 (formerly CBM33). The enzymes in this family were originally classified as chitin-binding proteins (CBM33); Vaaje-Kolstad et al. have shown that these proteins are in fact oxidative enzymes [PMID - 20929773]. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name CBM33, we recommend to describe these enzymes as "AA10 (formerly CBM33)".
Statistics GenBank accession (4694); Uniprot accession (382); PDB accession (35); 3D entries (19); cryst (0)
All (4546) Archaea (2) Bacteria (4339) Eukaryota (9) Viruses (162) unclassified (34) Structure (19) Characterized (22)
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 fusolin; spindle body protein (Gp37)   synthetic baculovirus AcMNPV-WIV-Syn1 ARJ58749.1    
 ORF   uncultured organism AGU11296.1    
 EKD16_04575   Streptomonospora sp. M2 QBI52722.1    
 EKD16_20580 (GbpA)   Streptomonospora sp. M2 QBI55875.1    
 EKD16_05960 (Cbha1)   Streptomonospora sp. M2 QBI52992.1    
 EKD16_19220   Streptomonospora sp. M2 QBI55607.1    
 ERC79_09320   Rhodococcus sp. ABRD24 QBJ96151.1    
 MG068_20090   Stenotrophomonas sp. ASS1 QBL42696.1    
 MG068_20085   Stenotrophomonas sp. ASS1 QBL42695.1    
 E3Z29_13755   Pseudomonas sp. S150 QBR31537.1    
 KTC_24020 (CpbD)   Thermosporothrix sp. COM3 BBH87651.1    
 KTC_16340   Thermosporothrix sp. COM3 BBH86883.1    
 DAIF1_40170 (Cpbd_1)   Stenotrophomonas sp. DAIF1 QBR46423.1    
 DAIF1_40180 (Cpbd_2)   Stenotrophomonas sp. DAIF1 QBR46424.1    
 EPZ47_02100 (GbpA)   Pseudomonas sp. 11K1 QBZ87549.1    
 EPZ47_11530   Pseudomonas sp. 11K1 QBZ89313.1    
 E4Z98_08360   Vagococcus sp. CF-49 QCA29328.1    
 E5N77_05685   Streptomyces sp. SS52 QCB21366.1    
 E5N77_04365   Streptomyces sp. SS52 QCB21142.1    
 E5N77_33640   Streptomyces sp. SS52 QCB26221.1    
 E5N77_13780   Streptomyces sp. SS52 QCB22776.1    
 E5N77_08385   Streptomyces sp. SS52 QCB21833.1    
 E5N77_02680   Streptomyces sp. SS52 QCB20850.1    
 E5790_10845   Stenotrophomonas sp. PAMC25021 QCB34148.1    
 E5790_10840   Stenotrophomonas sp. PAMC25021 QCB34147.1    
 E5225_17100   Cellulomonas sp. Z28 QCB95023.1    
 E5225_16290   Cellulomonas sp. Z28 QCB94888.1    
 E5225_01065   Cellulomonas sp. Z28 QCB92355.1    
 E5225_16305   Cellulomonas sp. Z28 QCB94891.1    
 E5225_16280   Cellulomonas sp. Z28 QCB94886.1    
 E5139_10020   Halomicrobium sp. ZP60 QCD65957.1    
 C9423_02955   Lactobacillus sp. Koumiss QCJ63386.1    
 C9423_13030   Lactobacillus sp. Koumiss QCJ65120.1    
 FCS00_16530   Elizabethkingia sp. 2-6 QCO47893.1    
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