Auxiliary Activity Family 10

Activities in FamilyAA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose; lytic cellulose monooxygenase (C1-hydroxylating) (EC; lytic cellulose monooxygenase (C4-dehydrogenating)(EC; lytic chitin monooxygenase (EC; lytic xylan monooxygenase / xylan oxidase (glycosidic bond-cleaving) (EC 1.14.99.-)
Mechanism monooxygenase
NoteAA10 (formerly CBM33). The enzymes in this family were originally classified as chitin-binding proteins (CBM33); Vaaje-Kolstad et al. have shown that these proteins are in fact oxidative enzymes [PMID - 20929773]. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name CBM33, we recommend to describe these enzymes as "AA10 (formerly CBM33)".
Statistics GenBank accession (6390); Uniprot accession (382); PDB accession (39); 3D entries (23); cryst (0)
All (6241) Archaea (5) Bacteria (6027) Eukaryota (9) Viruses (198) unclassified (2) Structure (23) Characterized (26)
Protein Name EC#OrganismGenBank UniprotPDB/3D
 dd_00295   Dictyostelium discoideum AX4 AAL93595.1
 ORF   Dictyostelium discoideum AX4 AAM43718.1    
 BN887_01428   Melanopsichium pennsylvanicum 4 CDI55928.1    
 ORF   Microsorum sp. SU-2018 AUX13428.1    
 SRS1_16126   Sporisorium reilianum f. sp. reilianum SRS1_H2-8 SJX65500.1    
 sr16126   Sporisorium reilianum SRZ2 CBQ69852.1    
 SPSC_01205   Sporisorium scitamineum SscI8 CDU22575.1    
 chitin binding protein Tectaria macrodonta AFR32946.1   6IF7[A]
 UBRO_07804   Ustilago bromivora UB2112 SAM85898.1    

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