Auxiliary Activity Family 10

Activities in FamilyAA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose; lytic cellulose monooxygenase (C1-hydroxylating) (EC; lytic cellulose monooxygenase (C4-dehydrogenating)(EC; lytic chitin monooxygenase (EC; lytic xylan monooxygenase / xylan oxidase (glycosidic bond-cleaving) (EC 1.14.99.-)
Mechanism monooxygenase
NoteAA10 (formerly CBM33). The enzymes in this family were originally classified as chitin-binding proteins (CBM33); Vaaje-Kolstad et al. have shown that these proteins are in fact oxidative enzymes [PMID - 20929773]. They are now reclassified in the AA category of CAZy. Because a significant literature is associated with the old name CBM33, we recommend to describe these enzymes as "AA10 (formerly CBM33)".
Statistics GenBank accession (6390); Uniprot accession (382); PDB accession (39); 3D entries (23); cryst (0)
All (6241) Archaea (5) Bacteria (6027) Eukaryota (9) Viruses (198) unclassified (2) Structure (23) Characterized (26)
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Hmuk_1372   Halomicrobium mukohataei DSM 12286 ACV47493.1 C7P321  
 GBQ70_10015   Halomicrobium mukohataei ZPS1 QFR20762.1    
 LC1Hm_0586 (CpbD) (fragment)   Halomicrobium sp. LC1Hm QGA81650.1    
 E5139_10020   Halomicrobium sp. ZP60 QCD65957.1    
 B1756_04075   Natrialbaceae archaeon JW/NM-HA 15 ARS89010.1    

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